ID   A6QU40_AJECN            Unreviewed;       448 AA.
AC   A6QU40;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   RecName: Full=FAD-binding domain-containing protein {ECO:0000259|Pfam:PF01494};
GN   ORFNames=HCAG_00896 {ECO:0000313|EMBL:EDN03032.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03032.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SIMILARITY: Belongs to the paxM FAD-dependent monooxygenase family.
CC       {ECO:0000256|ARBA:ARBA00007992}.
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DR   EMBL; CH476655; EDN03032.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QU40; -.
DR   STRING; 339724.A6QU40; -.
DR   VEuPathDB; FungiDB:HCAG_00896; -.
DR   HOGENOM; CLU_009665_19_5_1; -.
DR   OMA; RRMWEKN; -.
DR   OrthoDB; 5491711at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR002938; FAD-bd.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   PANTHER; PTHR13789; MONOOXYGENASE; 1.
DR   PANTHER; PTHR13789:SF309; PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED; 1.
DR   Pfam; PF01494; FAD_binding_3; 1.
DR   PRINTS; PR00420; RNGMNOXGNASE.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          12..377
FT                   /note="FAD-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01494"
SQ   SEQUENCE   448 AA;  49548 MW;  747CB594E46F0AAB CRC64;
     MASNTQATAP YTILILGGGI AGIASALALS KTLTPVLPNL KIIIYELRDV PSTSGGAINL
     TPVAHRHLDH LGVLDELQYL GPQGGVEVDE IEIFSSHSGK KMGAVDFAGK DGNGYGGYKG
     RRIMRICLHL ALISAVEKRS NIEMMFGKKV VGGIETDKCV TIYFEDGTFA KGDLALGCDG
     VHSATRSTIV DPDRISEYTG ISFIQATIKS EIIRSSKHFS VTALNRSRHG TMLTTYCDSE
     KENMFVAALA EVDEARLTYE ICKYQASDSW KTKSTAVMIL RDDIQNRFGK SAIPCIREIA
     EKCWDWFLYP VYQIHPGGKW YTERILLLGD AAHAMPPKDE SAAYALDDAI LFARVLTKYI
     HEPLSEAFRI YESIRRKTID HAYKTACENW AHNKDSGRLS NLLAEWITPL SLMRQKKKIT
     SAWVFDAMNV DISPPNPASR QSTASTVR
//