ID   A6QW04_AJECN            Unreviewed;       929 AA.
AC   A6QW04;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=Rho guanyl nucleotide exchange factor {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HCAG_01561 {ECO:0000313|EMBL:EDN03696.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN03696.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|EMBL:EDN03696.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NAm1 {ECO:0000313|EMBL:EDN03696.1};
RA   Ohara O., Nagase T., Kikuno R., Ishikawa K., Suyama M.;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDN03696.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NAm1 {ECO:0000313|EMBL:EDN03696.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Ma L.-J., Henn M.,
RA   Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA   Mauceli E., Brockman W., Rounsley S., Young S., LaButti K., Pushparaj V.,
RA   DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P.,
RA   Pearson M., Howarth C., Larson L., Luoma S., White J., Yandava C.,
RA   Kodira C., Zeng Q., Oleary S., Alvarado L., Taylor J., Sil A., Goldman B.;
RT   "Annotation of the Ajellomyces capsulatus (Histoplasma capsulatum)
RT   genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CH476655; EDN03696.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QW04; -.
DR   STRING; 339724.A6QW04; -.
DR   VEuPathDB; FungiDB:HCAG_01561; -.
DR   HOGENOM; CLU_007879_1_0_1; -.
DR   OMA; QPIYPRQ; -.
DR   OrthoDB; 23973at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd05992; PB1; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010481; Cdc24/Scd1_N.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   Pfam; PF06395; CDC24; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF15411; PH_10; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS51745; PB1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          167..346
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          831..927
FT                   /note="PB1"
FT                   /evidence="ECO:0000259|PROSITE:PS51745"
FT   REGION          563..734
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..589
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..724
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  104696 MW;  CBA892429A42C392 CRC64;
     MAEDNIINRR GGESLFQSCA SLKKRLSEVP GFEAHLAEME EMDRTEDAID PVASVWRCLR
     QGYPLMAIFN ASNPAEPLTI DTDKVPEARR PKAATFKFLQ ACLQDLEFPQ QDCFLITDLY
     GESTTGFVKV IKMVSRVLDI LEMRGLLYQP SIASAGPRQG EKVKLTRKEH ILKELLETER
     DYVHHLQNLQ ALKKELEETG ALNGDSSHQI FLNLNNLLDF AQRFLIRMEQ HNALPEDMQN
     WGDLFIQHQE GFRQYEPFIA NQLRCDAVCQ REWEKIKAAP RSADFQQMVA QPSTLNGFFV
     KPFQRLTKYP LMLMELKKQT DREDLVADVA TAIDMVQTVL DQANHAVDKE HLANAVEDLA
     SRVDDWKALK VEVFGELLRF GTFTVLKGDG GRDTERERVN IVAMDLYILP HLSFRTHTAL
     LQRCESQQAK DEADGQRQTK CCSKGKATTF KLKGRIYMAN VTEVLSVQKP GSYKIQIFWK
     GDPGVVDNFS IRYQNEDTMR KWCKDIDTQR AIQNEERATR HTGTSETEFT YLKMGPKIQN
     PYREEYEAEE ELVRESNTFS DFSVSRNASS TSLRARSATG GSSSSGPISI RPPRFPMPEP
     PLSVSTQFAN GAISPGDRNG NSYFSPVTDT TSTRSSSQST MFSYSRQGTP STPWTEDSNR
     YTAPAMPRAA SRDGTTSNPY FSNNNPRSAQ RPSLPPLSSS HHSQSSGISQ ARMRSASSPD
     IHHNSNIPES RRHVNGHSMQ TVDNVPVPPI PAHMASMIAP VNRSQNNSPI NNTLPIRAAT
     QSPGMQQRHG LPLNHFPEPR SQPLPTSNPM HSAISSPVNH GGEQELYMPS QLKAKVNFDD
     NYVTLVIASN ILFRSLIDRV DAKLARFTDR SIGNKSVRLR YRDEDGDFVT IDSDEAVQLA
     FMEWRDQHKN MLANGQVGEI QLFCQPVEN
//