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Database: UniProt
Entry: A6QW28_AJECN
LinkDB: A6QW28_AJECN
Original site: A6QW28_AJECN 
ID   A6QW28_AJECN            Unreviewed;       817 AA.
AC   A6QW28;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   25-OCT-2017, entry version 43.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=HCAG_01585 {ECO:0000313|EMBL:EDN03720.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=339724 {ECO:0000313|EMBL:EDN03720.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CH476655; EDN03720.1; -; Genomic_DNA.
DR   RefSeq; XP_001544538.1; XM_001544488.1.
DR   STRING; 339724.XP_001544538.1; -.
DR   EnsemblFungi; EDN03720; EDN03720; HCAG_01585.
DR   GeneID; 5450554; -.
DR   KEGG; aje:HCAG_01585; -.
DR   EuPathDB; FungiDB:HCAG_01585; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009297};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    427    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    487       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    507    527       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    562       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    601    621       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    720    743       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    749    773       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   817 AA;  92736 MW;  FE6BF4BA480D3FFF CRC64;
     MGVPQDTLLR SADMSLTQLY IANEIGREVV SALGEIGQVQ FRDLNPDTTA FQRTFTNEIR
     RLDNVDRQLR YFHSQLEKAG IPMRSSSEFS NTLAAPMASE IDELADRSES LEQRVTSLNE
     NYEALQKREI ELVEWRWVLR EAGGFFDRAH GHTEEIRQSF ENDEAPLLRD VEQQPARGQN
     GDAETQQAFS VMNIGFVAGV IPRDRIAALE RILWRTLRGN LYMNQSEIPE AIIDPSNNEK
     IHKNVFVIFA HGKEIIAKIR KISESLGANL YSVDENSELR RDQIHEVNTR VGDVGSFLRN
     TKSTLDAELT QIARSLAAWM IIVKKEKATY HTLNKFSYDQ ARKTLIAEAW CPTNSLPLIK
     ATLQDVNDRA GLSVPTIVNQ IRTNKTPPTY IKTNRFTEGF QVIINAYGTA KYGEVNPGLP
     TIITFPFLFA VMFGDFGHGM LMTMVATGMI LFERKLLKTK VDEITAMAFY GRYIMLMMGI
     FSMYPFGLDS AWHGTENDLL FANSFKMKLS VLLGWAHMTY SLCLSYINGR HFKRPIEIWG
     NFVPGMIFFQ SIFGYLTFTI IYKWCVDWNA RGQTPPGILN LLIFMFLKPG TVEEKLYPGQ
     GVVQVILLLV AVIQIPILLF LKPFYLRWEH NRTRALGYRG LGETARVSAL DGEDNGDSHI
     LGDGRTSIGN DADGIAMITQ DISEEEHEEF EFSEAMIHQI IHTIEFCLNC VSHTASYLRL
     WALSLAHQQL SVVLWTMTIG GAFSMESNVA RVIMIIATFY MWFTLTFAIL CVMEGTSAML
     HSLRLHWVEA MSKHFIGDGI PFLAFSFKTL LEEEPVD
//
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