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Database: UniProt
Entry: A6QX24
LinkDB: A6QX24
Original site: A6QX24 
ID   SEC11_AJECN             Reviewed;         187 AA.
AC   A6QX24;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   14-MAY-2014, entry version 38.
DE   RecName: Full=Signal peptidase complex catalytic subunit SEC11;
DE            EC=3.4.21.89;
DE   AltName: Full=Signal peptidase I;
GN   Name=SEC11; ORFNames=HCAG_01931;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Ajellomyces.
OX   NCBI_TaxID=339724;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
RA   Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
RA   Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
RA   Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
RA   Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens
RT   Coccidioides and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Catalytic component of the signal peptidase complex
CC       (SPC), which catalyzes the cleavage of N-terminal signal sequences
CC       of proteins targeted to the endoplasmic reticulum. Signal peptide
CC       cleavage occurs during the translocation (cotranslationally or
CC       post-translationally) through the translocon pore into the
CC       endoplasmic reticulum (By similarity).
CC   -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC       leader sequences from secreted and periplasmic proteins.
CC   -!- SUBUNIT: Component of the signal peptidase complex (SPC) (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type II membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the peptidase S26B family.
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DR   EMBL; CH476655; EDN04066.1; -; Genomic_DNA.
DR   RefSeq; XP_001544884.1; XM_001544834.1.
DR   MEROPS; S26.010; -.
DR   GeneID; 5450828; -.
DR   KEGG; aje:HCAG_01931; -.
DR   KO; K13280; -.
DR   OrthoDB; EOG7BCNQ4; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR   Gene3D; 2.10.109.10; -; 1.
DR   InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR   InterPro; IPR028360; Peptidase_S24/S26_b-rbn.
DR   InterPro; IPR019759; Peptidase_S24_S26.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   InterPro; IPR001733; Peptidase_S26B.
DR   PANTHER; PTHR10806; PTHR10806; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00728; SIGNALPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
DR   PROSITE; PS00501; SPASE_I_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase;
KW   Membrane; Protease; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN         1    187       Signal peptidase complex catalytic
FT                                subunit SEC11.
FT                                /FTId=PRO_0000412309.
FT   TOPO_DOM      1     18       Cytoplasmic (Potential).
FT   TRANSMEM     19     39       Helical; Signal-anchor for type II
FT                                membrane protein; (Potential).
FT   TOPO_DOM     40    187       Lumenal (Potential).
FT   ACT_SITE     53     53       By similarity.
FT   CARBOHYD    125    125       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   187 AA;  20634 MW;  3A0A1CD1BB457D4E CRC64;
     MLSSLSPYMA NPRNTLSQVL NFGLVLSSAF MVWKALSVIT NSASPVVVVL SGSMEPAFQR
     GDLLFLWNRS PRVDVGEIVV YNVQGKDIPI VHRVMRVFPD VPTTGAKDVE GVEASQKLLT
     KGDNNLSDDT ELYAPGQEFL DRKTDLMGSV RGYVPAIGYV TIMLSEHPWL KSVLLGFMGL
     MVMLQRE
//
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