ID A6QZJ4_AJECN Unreviewed; 549 AA.
AC A6QZJ4;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDN06198.1};
GN ORFNames=HCAG_02801 {ECO:0000313|EMBL:EDN06198.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN06198.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
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DR EMBL; CH476656; EDN06198.1; -; Genomic_DNA.
DR AlphaFoldDB; A6QZJ4; -.
DR STRING; 339724.A6QZJ4; -.
DR VEuPathDB; FungiDB:HCAG_02801; -.
DR HOGENOM; CLU_024219_3_1_1; -.
DR OMA; EWDVYKA; -.
DR OrthoDB; 11439at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0006914; P:autophagy; IEA:InterPro.
DR Gene3D; 6.10.250.3110; -; 1.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR041691; Atg6/beclin_CC.
DR InterPro; IPR040455; Atg6_BARA.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR Pfam; PF04111; APG6; 1.
DR Pfam; PF17675; APG6_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT DOMAIN 166..294
FT /note="Atg6/beclin coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF17675"
FT DOMAIN 297..529
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
FT REGION 32..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 231..300
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 33..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 61022 MW; 50AB3721E249096F CRC64;
MYCQKCRTPL KVDGSLEDLN PAAFDLLIGS TGKSLPDPSS KSTSRAAFPP DRQQRYDQVS
RRATSPVYKR TVPAPRYSTG NPLGQSRTGP KDGPGMSFVM LSESQVVPAH TAPTVNGDVR
RPSKGSLRNL SEAQTIEHGT QTYPDQIDKT TRLFEIVSAR SDIDHPICTE CTEMLIEGLQ
KRLQTATKER DAYVSFLKNL NNSIPSPEEV QAAEDDLKAT LQAEEDAFQE LLALEKEKAA
VDLEIAELEE ESRKLDLEEE QFWSDRNAFA LKLSDFQNER DALNMKYDHD SRQLERLQRT
NVYNDTFCIG HDGYFGTING LRLGRLANLS VEWSEINAAW GQTLLLLATV ADKLGFQFQG
YKLKPLGSTS RIEKIEYPQQ SPNATTSHRS PSSNRPDTTL TPKITSLDLY SSGDLPLHLP
WLHRRFDAGM VAFLECLRQL GEHVEHTPVS LPSRSPPPRL SRYQSPGISS PATRLQAQIS
GLKLPYEIKR DKIGDASIKL GFNQSDETWT RACKYTLTCC KFLLAHASNV TSAGSGPPVP
ATAAIVPNR
//
