ID   A6QZY5_AJECN            Unreviewed;       886 AA.
AC   A6QZY5;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Integrase catalytic domain-containing protein {ECO:0000259|PROSITE:PS50994};
GN   ORFNames=HCAG_02942 {ECO:0000313|EMBL:EDN06339.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN06339.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476656; EDN06339.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6QZY5; -.
DR   VEuPathDB; FungiDB:HCAG_02942; -.
DR   HOGENOM; CLU_000384_38_1_1; -.
DR   OMA; SEICERW; -.
DR   OrthoDB; 2150499at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR24559:SF437; RIBONUCLEASE H; 1.
DR   PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT   DOMAIN          675..841
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   COILED          859..886
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   886 AA;  101575 MW;  C07A79320992EAC8 CRC64;
     MKIIDDEHVL REGFHHFEEA DMSGYDVILA SNISHVHLDT AKEFATLMDN SNIIFAAFPL
     RAAHAATEPN IPDDYKDYLD VFREDIPDAE HAPHDHAIDL KPGKEPPYRP IYNLSPQELS
     VLREYIEKAL EKNWIRPSKS PAGAPVLFAP KKDGTLRLCV DYRGLNEITV KNRYPLPLIS
     EILDRIRIRA GDEWKTAFRT RYGHFEYLVL PFGLTNAPAT FQSYINKALS DILDVYCVAY
     LDDIVIYSNT LDEHVAHVKN VLEQIGFLGF VITTQGITVE KRRVDTILDW PEPRTINELQ
     TFLGFANFYR RFIYKFSIIT APLTELLKGY ETKKGKNNAP VQLNENCKHA ILQLKECFTE
     APLLVHFDPQ RKLRIETDGS GVAIAAVISQ LMDDGHWHPI AFWSRKLTEA ERRYQTYDLE
     MLPIVEAFRQ WRHYLHGSRH PIVVLSDHAN LRRFMTTKQL NGRQIRWMQM LSAFDFEIEH
     HPGENNPADA PSRHSDYIKH AAPLTGLPTL QEKLHENEVA GVTGLDLGTL VPRILAVKVF
     ESEIAYREEV AESIVELLLQ VQNRDAGTSE LRRRLEVGDA SVGDRSTWAV DKDGLLRKDG
     KVYVPQDKAV RHEIMKMNHD DPQGGHFGRD KTIEAIKRKY SWHGMSDEIA EYVRTCDVCQ
     RVKIPRHKPY GLLQPHPVPD KKWHTISMDF IEGLPDNKKG SQTYNAIVVF VDSFTKWAII
     VPTSSKLDAE GLADIIVWKL AKNFGLPANI ISDRDSLINS KFWSTLCYLL HVRRKLSTAF
     HPQTDGQTER LNQVIEHYLR TYCSYQQDNW IEWIPLAQWA YNNAFHASIK MTPSEAMIGR
     PTELRIDVEP PSTGASKSAI EQVERMKQAE NRIRECLEAA KAAEKK
//