ID A6R0W2_AJECN Unreviewed; 791 AA.
AC A6R0W2;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_03269 {ECO:0000313|EMBL:EDN06739.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN06739.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; CH476657; EDN06739.1; -; Genomic_DNA.
DR AlphaFoldDB; A6R0W2; -.
DR VEuPathDB; FungiDB:HCAG_03269; -.
DR HOGENOM; CLU_002458_0_0_1; -.
DR OMA; SEPIRHD; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..195
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 217..424
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 436..678
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 758..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 791 AA; 90170 MW; 631A71C1D55CE060 CRC64;
MKIAGNAVLV SSALSLATGK NSSGDGGGDG EHRFQDQTKG QRDLLTQVIV SCTVGFLAFM
GFCILRPKWR ELYAARRRLR TAASRLPELP DTLFGWIPIV HKISDDEVLA SAGLDAFVFL
SFYTYAIKFL RVVFFFTLAV ILPIHYIYTK KYGYPWDMPE DHKDDPQKSK ANPTYLWMHV
VFAYIFTGIG ISFLIDHTNK IIQIRQQWLG AQTTLTDRTL RLSGIPPELR SEEKITQCIE
QFQIGKVDQV MLCRDWSELD GLMEARKNIL QKLEEAWTKH VGYRWQRSDT RGIALPLVQT
DRMAATFDSN ENSERSRLLS AEESARAHVS SYNLKRPTTR IWYGPLNLRF KTIDAIDFYE
EKLRQLDERI EEIRKKECEP IPLAFVTMES IAACQMAVQA ILDPWPMQLV ANLAPAPADV
VWQHTYLSRR SRMLRGWSIT LLIGVLTVFW SVLLIPLAYL LNLETIEKVI PSLADFLSRH
AITKSLVQTG LPTLILSLMT IAVPFIYDWL GNLQGMTSQG DVELSLISKN FFFTFFNLFL
VFTVFATASN FYRFFENLRD VLRDTTTIAL ALARSLETLA PFYTNLIVLQ GLGLFPFRLL
EFGSVFLYPF QRFSARTPRD YAGLDKPPTF SYGLALPQTI LIFIITVVYS VFPSSYIVCL
FGLIYFSIGR FIYKYQLLLR HGSPATQHRP RMGHDLLPRH SKAHRLRLAS SWDRDAVPLR
FRGQDLASKL KKYVNPNLVV PLDEPWIPGR AAAHAIINSP DTGGDTVTES SHDDNTGTRT
NGNRIRRDMG H
//
