ID A6R1A0_AJECN Unreviewed; 553 AA.
AC A6R1A0;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=PUM-HD domain-containing protein {ECO:0000259|PROSITE:PS50303};
GN ORFNames=HCAG_03407 {ECO:0000313|EMBL:EDN06877.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN06877.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit. {ECO:0000256|ARBA:ARBA00024893}.
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DR EMBL; CH476657; EDN06877.1; -; Genomic_DNA.
DR AlphaFoldDB; A6R1A0; -.
DR STRING; 339724.A6R1A0; -.
DR VEuPathDB; FungiDB:HCAG_03407; -.
DR HOGENOM; CLU_013994_1_0_1; -.
DR OMA; YGPEFSI; -.
DR OrthoDB; 5479527at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012959; CPL_dom.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR040059; PUM3.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13389:SF0; PUMILIO HOMOLOG 3; 1.
DR PANTHER; PTHR13389; UNCHARACTERIZED; 1.
DR Pfam; PF08144; CPL; 1.
DR SMART; SM00025; Pumilio; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 140..546
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..74
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 62054 MW; AF5C98A7410C106D CRC64;
MAGIKRRFDT ADGRDGKRTK VKDGGRVNKN KPVVESKSKS KKPQPKVESS EDDEEEEDFN
FSEEGVDVDD SPSDSEDTTQ PQKLKTRSKG LNSSEKQANG TGGGALSVKS GTSSKESHAK
QKALAQERKA AKPNSDLIAR SKKLWERLRR KSHVPLEERK KLVAELYSII TGRVKEFVFK
HDSVRVIQTA LKYATPQQRK DIAKELKGNY CSLAESKYAK FLIGKLLVHG DSEVRDIIIP
EFYGHVKRLM RHPEASWIVD DIYRTVATAT QRAMLLREWY GAEFVVFRPA DGVPETADLA
EIISKNPEKR GPIMKYLHEF TNHLVQKKFT GFTMLHDAML QYFLNTTPGS EEAAELVQLI
LGDEEGDLAK NLAFTKSGAR LVSLCFAYSN AKDRKLLLRL YRGTMKMLAG DVNGQVVLLT
AYEVIDDTKL SSKSIFPELL NQASTAEARH EELLLQIIDL TARIPVLYPF AEDTTRWLVT
DPDHKKILDE VLAIRSQTSK KDPNTRRQEL VKAASPTLLE FIAASADSLV EYSFGCQFIT
EVLFSADGDK QPP
//
