ID   A6RCE8_AJECN            Unreviewed;       246 AA.
AC   A6RCE8;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=SGNH hydrolase-type esterase domain-containing protein {ECO:0000259|Pfam:PF13472};
GN   ORFNames=HCAG_07306 {ECO:0000313|EMBL:EDN10845.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN10845.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476662; EDN10845.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RCE8; -.
DR   STRING; 339724.A6RCE8; -.
DR   VEuPathDB; FungiDB:HCAG_07306; -.
DR   HOGENOM; CLU_051989_0_0_1; -.
DR   OMA; HEPAWEK; -.
DR   OrthoDB; 1106721at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   CDD; cd01838; Isoamyl_acetate_hydrolase_like; 1.
DR   Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR   InterPro; IPR045136; Iah1-like.
DR   InterPro; IPR013830; SGNH_hydro.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR14209; ISOAMYL ACETATE-HYDROLYZING ESTERASE 1; 1.
DR   PANTHER; PTHR14209:SF19; ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG; 1.
DR   Pfam; PF13472; Lipase_GDSL_2; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          31..218
FT                   /note="SGNH hydrolase-type esterase"
FT                   /evidence="ECO:0000259|Pfam:PF13472"
FT   REGION          156..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   246 AA;  27087 MW;  F3779803F091D747 CRC64;
     MKTLWCQLAQ FGRGKQPLNS PPYVEYEQFI IFGDSITQGS CDQGRGFAFS PALQSDYIRR
     FDIINRGFSG YTSQQALAIF PCFFPPVQKA KVRLMIVFFG ANDAVLPGFE QHVPLPTYEA
     NLRKILTHPL IKEHKETNLL LLTPPPVDEY QFSAADTDTD TDMGTDTPSG TPEPASVAVM
     RKASQTKKYA DACRQVGNAL NVPVADIWTA FMTAAGWVEG QPLPGSRDAP ANKKLQALLS
     DDAPKL
//