ID   A6RCU8_AJECN            Unreviewed;       534 AA.
AC   A6RCU8;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN   ORFNames=HCAG_07456 {ECO:0000313|EMBL:EDN10995.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN10995.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476662; EDN10995.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RCU8; -.
DR   VEuPathDB; FungiDB:HCAG_07456; -.
DR   HOGENOM; CLU_000288_34_13_1; -.
DR   OrthoDB; 2124805at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46082:SF11; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR46082; ATP/GTP-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          399..534
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          189..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..213
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  60966 MW;  2633DDC316C3E736 CRC64;
     MPLQPSKQRE QQPLIRSTLV QTPSQVMSSI MDRAKYTVGW IALLPLELAA AKGMLEGANT
     MFVMGVQPKM GGGVPSYGPP GAKSEIVLGD VVVSVPFRDY GGVVRYDFGA WIERGHLEMR
     GHINGPSPRL LETVKLLKEH HQAHGRANLP LYIQEMRTRI DRDERDKFED PGALKDNLFV
     GYDHPERFQD QPCEGHCDPR QSKNRESRGN EASRPVDTPK IQYGNIASSN QLQISECMRE
     NLQKKLQVIC FEMEGAGVIQ GHDCLVVRGI CDYSDSHKNK TWQYYAAATA AAYAKEFLRM
     MPKSENAATS DPLLLLKEYY FKNDLLRIER LSGALLDMEQ CYINLTIVEH KKQLSESPTD
     MPFSLFSRLK VEATVQDERI SLPSLFEERK LGDKILLPKR IFIRGRAGVG KTTLCKKIVH
     DYFQNNMWKQ WFDCILWIPL RRLKTQLQEN KEYRNFGDIF YNEYFLSHND GEALAKLLWS
     MVSDHVYSGR ILFILDGMDE VSRELKSGTD TGKLLDELLA WPQVIVTSRP LGRS
//