ID   A6RED7_AJECN            Unreviewed;       693 AA.
AC   A6RED7;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=Histone deacetylase domain-containing protein {ECO:0000259|Pfam:PF00850};
GN   ORFNames=HCAG_08002 {ECO:0000313|EMBL:EDN04336.1};
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN04336.1, ECO:0000313|Proteomes:UP000009297};
RN   [1] {ECO:0000313|Proteomes:UP000009297}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
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DR   EMBL; CH476664; EDN04336.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6RED7; -.
DR   STRING; 339724.A6RED7; -.
DR   VEuPathDB; FungiDB:HCAG_08002; -.
DR   HOGENOM; CLU_397371_0_0_1; -.
DR   OrthoDB; 10780at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0009889; P:regulation of biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR47558; HISTONE DEACETYLASE HOS3; 1.
DR   PANTHER; PTHR47558:SF1; HISTONE DEACETYLASE HOS3; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT   DOMAIN          3..209
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          266..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          649..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..542
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        549..564
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..594
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  75392 MW;  A78F4B0C508C27BE CRC64;
     MSHGLTHAAI IDFDLHHGDG SQDIAWEQNR KASAASRNSP SHKKTAIGYF SLHDINSYPC
     EAGDVNKVRN ASVCIDNAHG QSVWNIHLEP WKTSAGFWEL YNTKYSILLE KARNFLRYHT
     QRLINSQNPS LPKAAIFISA GFDASEWEGV GMQRHKVNVP TDFYAKFTAD IVQIAEDEAL
     GVDGRVISVL EGGYSDRALI SGVLSHLSGL ADSQRTGFEN GDNRLATEMI SRLGLNDCPE
     TVLEEDSTFD TEWWTLPMLE TLELLANPPP PTPARKSREK GPPTYCSPTQ ASAAKIVLPS
     RDRRSISSQL SAGDSGYPRL PLPVVDWATA AYEMSKVLIP TNRQTVSLQH SELKGENTRT
     KRDRHSTSNV SELNAADDRK PMQLRERKPK PPSPEHLTTK QPSKASRRAT IASVSDIPDA
     SATEPPESCN QNPKPVDSHS SRRLSVASTV ASTGGARSRG SVEETSPPSS NGSSARRIDS
     RRGTSNGKSG EPLTVKKLGG VRTSPRKPSA ARQARPIGGG PIPPVRSSSI NTDTSERDLT
     NLSAVPSPEE HAAREEERRK IATSRSASRK SQTSKASRSS STTATGKVSN PDTALAQSPP
     PPPVAGTTLS TRFDPIKQEM AHLPHKNSDI EGIPIPDLSS FPHSANSYSE VVRGWPSDPT
     TKRTHIEPSK NPSPATKKLS IVLARKLRRN EIH
//