ID A6T7I4_KLEP7 Unreviewed; 572 AA.
AC A6T7I4;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=PTS family enzyme IIBC, glucitol/sorbitol-specific {ECO:0000313|EMBL:ABR76555.1};
GN ORFNames=KPN_01122 {ECO:0000313|EMBL:ABR76555.1};
OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=272620 {ECO:0000313|EMBL:ABR76555.1, ECO:0000313|Proteomes:UP000000265};
RN [1] {ECO:0000313|EMBL:ABR76555.1, ECO:0000313|Proteomes:UP000000265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578 {ECO:0000313|Proteomes:UP000000265};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [2] {ECO:0000313|EMBL:ABR76555.1, ECO:0000313|Proteomes:UP000000265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578 {ECO:0000313|Proteomes:UP000000265};
RG The Klebsiella pneumonia Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the four-carbon acid sugar kinase family.
CC {ECO:0000256|ARBA:ARBA00005715}.
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DR EMBL; CP000647; ABR76555.1; -; Genomic_DNA.
DR RefSeq; WP_015958188.1; NC_009648.1.
DR AlphaFoldDB; A6T7I4; -.
DR STRING; 272620.KPN_01122; -.
DR jPOST; A6T7I4; -.
DR PaxDb; 272620-KPN_01122; -.
DR DNASU; 5341022; -.
DR EnsemblBacteria; ABR76555; ABR76555; KPN_01122.
DR KEGG; kpn:KPN_01122; -.
DR HOGENOM; CLU_029424_0_1_6; -.
DR Proteomes; UP000000265; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.980.20; Four-carbon acid sugar kinase, nucleotide binding domain; 1.
DR Gene3D; 3.40.50.10840; Putative sugar-binding, N-terminal domain; 1.
DR InterPro; IPR010737; 4-carb_acid_sugar_kinase_N.
DR InterPro; IPR037051; 4-carb_acid_sugar_kinase_N_sf.
DR InterPro; IPR031475; NBD_C.
DR InterPro; IPR042213; NBD_C_sf.
DR InterPro; IPR011618; PTS_EIIBC_GUT_N.
DR InterPro; IPR004702; PTS_sorb_EIIBC.
DR PANTHER; PTHR39427; -; 1.
DR PANTHER; PTHR39427:SF1; PTS SYSTEM GLUCITOL_SORBITOL-SPECIFIC EIIB COMPONENT; 1.
DR Pfam; PF03612; EIIBC-GUT_N; 1.
DR Pfam; PF17042; NBD_C; 1.
DR Pfam; PF07005; SBD_N; 1.
DR SUPFAM; SSF142764; YgbK-like; 1.
DR PROSITE; PS51102; PTS_EIIB_TYPE_5; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..214
FT /note="PTS EIIB type-5"
FT /evidence="ECO:0000259|PROSITE:PS51102"
FT MOD_RES 72
FT /note="Phosphocysteine; by EIIA"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00425"
SQ SEQUENCE 572 AA; 61244 MW; 64C4679E4C05DA09 CRC64;
MEKHLLISKG CKGWGGPLTI TPGQGKKIAY ITGGIRPPVV DRLSELTGWP SIDVFKNGEP
PAEEIGLMVI DCGGTLRCGL YPKRGIPTIN LHPTGKSGPL AEFIHEGIYV SGVTPACIEM
VWPQGEGGKL GIVADDLTGA TTVGVLLARS GLKTAAFFDT ESFARNEVEY PAMVVSSDSR
PLPKAEAQHK VSAAVKQLQA RGAHYFTKRI DTTLRGGIGF EIDAMLEQLP QETVAVVVPA
MPQSRRILVG GYSVIDSVAL SRTDVARDVR TPVTESWVPG LLAAQTHHQV GHIALTSVMK
GEGQIQQDLQ EQQQRGVRVI VVDAITVDDV DAIAGAVVAL NWNVLTVDPG PFTERLAVRR
GLMREARSSA PASLTADGQR GSILIVAGSA TPVTKKQLQY LIANDARVCH IPVDAELLVD
RKNAAEIEVN RVVQHARQCV PAQHNALFVF ESALTGRLLN LQEEEQRFGL AHGEAAQNIN
HGLGSIVREV LNCASGEIKG LYMTGGDTMV NVLKELGATG IEMIDYVIPQ TDMVRIIGGD
YAGLICVGKG GLTGPEDIIS IIVDRIYQEA QQ
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