ID TRUD_KLEP7 Reviewed; 349 AA.
AC A6TD37;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 01-MAY-2013, entry version 39.
DE RecName: Full=tRNA pseudouridine synthase D;
DE EC=5.4.99.27;
DE AltName: Full=tRNA pseudouridine(13) synthase;
DE AltName: Full=tRNA pseudouridylate synthase D;
DE AltName: Full=tRNA-uridine isomerase D;
GN Name=truD; OrderedLocusNames=KPN78578_30470; ORFNames=KPN_03107;
OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH
OS 78578).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Klebsiella.
OX NCBI_TaxID=272620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578;
RG The Klebsiella pneumonia Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC 13 in transfer RNAs (By similarity).
CC -!- CATALYTIC ACTIVITY: tRNA uridine(13) = tRNA pseudouridine(13).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase TruD family.
CC -!- SIMILARITY: Contains 1 TRUD domain.
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DR EMBL; CP000647; ABR78508.1; -; Genomic_DNA.
DR RefSeq; YP_001336738.1; NC_009648.1.
DR ProteinModelPortal; A6TD37; -.
DR SMR; A6TD37; 1-340.
DR STRING; 272620.KPN_03107; -.
DR PRIDE; A6TD37; -.
DR EnsemblBacteria; ABR78508; ABR78508; KPN_03107.
DR GeneID; 5338561; -.
DR KEGG; kpn:KPN_03107; -.
DR PATRIC; 20460530; VBIKlePne13394_3123.
DR eggNOG; COG0585; -.
DR HOGENOM; HOG000224848; -.
DR KO; K06176; -.
DR OMA; ALTRQWF; -.
DR ProtClustDB; PRK00984; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR HAMAP; MF_01082; TruD; 1; -.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR001656; PsdUridine_synth_TruD.
DR InterPro; IPR020119; PsdUridine_synth_TruD_CS.
DR InterPro; IPR011760; PsdUridine_synth_TruD_insert.
DR PANTHER; PTHR13326; PTHR13326; 1.
DR Pfam; PF01142; TruD; 1.
DR SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR TIGRFAMs; TIGR00094; tRNA_TruD_broad; 1.
DR PROSITE; PS50984; TRUD; 1.
DR PROSITE; PS01268; UPF0024; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; tRNA processing.
FT CHAIN 1 349 tRNA pseudouridine synthase D.
FT /FTId=PRO_1000084747.
FT DOMAIN 155 303 TRUD.
FT ACT_SITE 80 80 Nucleophile (By similarity).
FT BINDING 27 27 Substrate (By similarity).
FT BINDING 129 129 Substrate (By similarity).
FT BINDING 329 329 Substrate (By similarity).
SQ SEQUENCE 349 AA; 39103 MW; FFD06FF60C782814 CRC64;
MIAFDQLTWL HGKPQSSGLL KANPEDFLVV EDLGFAPDGE GEHVLVRILK NGCNTRFVAD
ALAKFLKIHA REVSFAGQKD KHAVTEQWLC ARVPGKEMPD LSKFQLEGCQ VLEYARHKRK
LRLGALKGNQ FTVILREISD RQDVETRLQA IAERGVPNYF GAQRFGIGGS NLQGALRWAE
SGAPVRDRNK RSFWLSAARS ALFNQQVSIR LKKTEFNQVV DGDALQLAGR GSWFVVTPEE
LEVSQARVHN RELMITATLP GSGDWGSQRD ALAFEQAAIA EETALQALLV REKVEAARRA
MLLYPQQLSW NWWDDVTVEL RFWLPAGSFA TSVVRELINT TGDYANIAE
//
