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Database: UniProt
Entry: A6TD37
LinkDB: A6TD37
Original site: A6TD37 
ID   TRUD_KLEP7              Reviewed;         349 AA.
AC   A6TD37;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   01-OCT-2014, entry version 45.
DE   RecName: Full=tRNA pseudouridine synthase D {ECO:0000255|HAMAP-Rule:MF_01082};
DE            EC=5.4.99.27 {ECO:0000255|HAMAP-Rule:MF_01082};
DE   AltName: Full=tRNA pseudouridine(13) synthase {ECO:0000255|HAMAP-Rule:MF_01082};
DE   AltName: Full=tRNA pseudouridylate synthase D {ECO:0000255|HAMAP-Rule:MF_01082};
DE   AltName: Full=tRNA-uridine isomerase D {ECO:0000255|HAMAP-Rule:MF_01082};
GN   Name=truD {ECO:0000255|HAMAP-Rule:MF_01082};
GN   OrderedLocusNames=KPN78578_30470; ORFNames=KPN_03107;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH
OS   78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-
CC       13 in transfer RNAs. {ECO:0000255|HAMAP-Rule:MF_01082}.
CC   -!- CATALYTIC ACTIVITY: tRNA uridine(13) = tRNA pseudouridine(13).
CC       {ECO:0000255|HAMAP-Rule:MF_01082}.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruD family.
CC       {ECO:0000255|HAMAP-Rule:MF_01082}.
CC   -!- SIMILARITY: Contains 1 TRUD domain. {ECO:0000255|HAMAP-
CC       Rule:MF_01082}.
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DR   EMBL; CP000647; ABR78508.1; -; Genomic_DNA.
DR   RefSeq; YP_001336738.1; NC_009648.1.
DR   ProteinModelPortal; A6TD37; -.
DR   SMR; A6TD37; 1-340.
DR   STRING; 272620.KPN_03107; -.
DR   PRIDE; A6TD37; -.
DR   EnsemblBacteria; ABR78508; ABR78508; KPN_03107.
DR   GeneID; 5338561; -.
DR   KEGG; kpn:KPN_03107; -.
DR   PATRIC; 20460530; VBIKlePne13394_3123.
DR   eggNOG; COG0585; -.
DR   HOGENOM; HOG000224848; -.
DR   KO; K06176; -.
DR   OMA; ALTRQWF; -.
DR   OrthoDB; EOG6FRCSP; -.
DR   BioCyc; KPNE272620:GKDC-3107-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_01082; TruD; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR001656; PsdUridine_synth_TruD.
DR   InterPro; IPR020119; PsdUridine_synth_TruD_CS.
DR   InterPro; IPR011760; PsdUridine_synth_TruD_insert.
DR   PANTHER; PTHR13326; PTHR13326; 1.
DR   Pfam; PF01142; TruD; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00094; tRNA_TruD_broad; 1.
DR   PROSITE; PS50984; TRUD; 1.
DR   PROSITE; PS01268; UPF0024; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; Reference proteome; tRNA processing.
FT   CHAIN         1    349       tRNA pseudouridine synthase D.
FT                                /FTId=PRO_1000084747.
FT   DOMAIN      155    303       TRUD. {ECO:0000255|HAMAP-Rule:MF_01082}.
FT   ACT_SITE     80     80       Nucleophile. {ECO:0000255|HAMAP-
FT                                Rule:MF_01082}.
FT   BINDING      27     27       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01082}.
FT   BINDING     129    129       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01082}.
FT   BINDING     329    329       Substrate. {ECO:0000255|HAMAP-
FT                                Rule:MF_01082}.
SQ   SEQUENCE   349 AA;  39103 MW;  FFD06FF60C782814 CRC64;
     MIAFDQLTWL HGKPQSSGLL KANPEDFLVV EDLGFAPDGE GEHVLVRILK NGCNTRFVAD
     ALAKFLKIHA REVSFAGQKD KHAVTEQWLC ARVPGKEMPD LSKFQLEGCQ VLEYARHKRK
     LRLGALKGNQ FTVILREISD RQDVETRLQA IAERGVPNYF GAQRFGIGGS NLQGALRWAE
     SGAPVRDRNK RSFWLSAARS ALFNQQVSIR LKKTEFNQVV DGDALQLAGR GSWFVVTPEE
     LEVSQARVHN RELMITATLP GSGDWGSQRD ALAFEQAAIA EETALQALLV REKVEAARRA
     MLLYPQQLSW NWWDDVTVEL RFWLPAGSFA TSVVRELINT TGDYANIAE
//
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