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Database: UniProt
Entry: A6U4R9
LinkDB: A6U4R9
Original site: A6U4R9 
ID   PTU3C_STAA2             Reviewed;         688 AA.
AC   A6U4R9;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   16-APR-2014, entry version 56.
DE   RecName: Full=PTS system glucoside-specific EIICBA component;
DE   Includes:
DE     RecName: Full=Glucoside permease IIC component;
DE     AltName: Full=PTS system glucoside-specific EIIC component;
DE   Includes:
DE     RecName: Full=Glucoside-specific phosphotransferase enzyme IIB component;
DE              EC=2.7.1.69;
DE     AltName: Full=PTS system glucoside-specific EIIB component;
DE   Includes:
DE     RecName: Full=Glucoside-specific phosphotransferase enzyme IIA component;
DE              EC=2.7.1.-;
DE     AltName: Full=PTS system glucoside-specific EIIA component;
GN   Name=glcB; OrderedLocusNames=SaurJH1_2614;
OS   Staphylococcus aureus (strain JH1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=359787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JH1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Tomasz A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Staphylococcus aureus subsp.
RT   aureus JH1.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar
CC       phosphotransferase system (sugar PTS), a major carbohydrate active
CC       -transport system, catalyzes the phosphorylation of incoming sugar
CC       substrates concomitantly with their translocation across the cell
CC       membrane. This system is involved in alpha- and beta-glucoside
CC       transport (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein EIIB N(pi)-phospho-L-
CC       histidine/cysteine + sugar = protein EIIB + sugar phosphate.
CC   -!- CATALYTIC ACTIVITY: Protein EIIA N(pi)-phospho-L-histidine +
CC       protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-
CC       histidine/cysteine.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (By similarity).
CC   -!- DOMAIN: The EIIC domain forms the PTS system translocation channel
CC       and contains the specific substrate-binding site.
CC   -!- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a
CC       cysteinyl or histidyl residue, depending on the transported sugar.
CC       Then, it transfers the phosphoryl group to the sugar substrate
CC       concomitantly with the sugar uptake processed by the EIIC domain.
CC   -!- DOMAIN: The EIIA domain is phosphorylated by phospho-HPr on a
CC       histidyl residue. Then, it transfers the phosphoryl group to the
CC       EIIB domain.
CC   -!- SIMILARITY: Contains 1 PTS EIIA type-1 domain.
CC   -!- SIMILARITY: Contains 1 PTS EIIB type-1 domain.
CC   -!- SIMILARITY: Contains 1 PTS EIIC type-1 domain.
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DR   EMBL; CP000736; ABR53437.1; -; Genomic_DNA.
DR   RefSeq; YP_001317724.1; NC_009632.1.
DR   ProteinModelPortal; A6U4R9; -.
DR   SMR; A6U4R9; 447-509.
DR   STRING; 359787.SaurJH1_2614; -.
DR   EnsemblBacteria; ABR53437; ABR53437; SaurJH1_2614.
DR   GeneID; 5316195; -.
DR   KEGG; sah:SaurJH1_2614; -.
DR   PATRIC; 19537214; VBIStaAur98826_2665.
DR   eggNOG; COG1263; -.
DR   HOGENOM; HOG000250993; -.
DR   KO; K02763; -.
DR   KO; K02764; -.
DR   KO; K02765; -.
DR   OMA; RPENKKV; -.
DR   OrthoDB; EOG6FFS9V; -.
DR   ProtClustDB; CLSK872840; -.
DR   BioCyc; SAUR359787:GCG4-2692-MONOMER; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005351; F:sugar:hydrogen symporter activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1360.60; -; 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR018113; PTrfase_EIIB/Cys_phosph_CS.
DR   InterPro; IPR001127; PTS_EIIA_1_perm.
DR   InterPro; IPR001996; PTS_EIIB_1.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR013013; PTS_EIIC_1.
DR   InterPro; IPR011535; PTS_Glc-like_IIB_component.
DR   InterPro; IPR011299; PTS_IIBC_glc.
DR   Pfam; PF00358; PTS_EIIA_1; 1.
DR   Pfam; PF00367; PTS_EIIB; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   SUPFAM; SSF51261; SSF51261; 1.
DR   SUPFAM; SSF55604; SSF55604; 1.
DR   TIGRFAMs; TIGR00826; EIIB_glc; 1.
DR   TIGRFAMs; TIGR00830; PTBA; 1.
DR   TIGRFAMs; TIGR02002; PTS-II-BC-glcB; 1.
DR   PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR   PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
DR   PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR   PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR   PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Kinase; Membrane;
KW   Phosphotransferase system; Sugar transport; Transferase;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    688       PTS system glucoside-specific EIICBA
FT                                component.
FT                                /FTId=PRO_5000257148.
FT   TRANSMEM     12     32       Helical; (Potential).
FT   TRANSMEM     81    101       Helical; (Potential).
FT   TRANSMEM    137    157       Helical; (Potential).
FT   TRANSMEM    182    202       Helical; (Potential).
FT   TRANSMEM    223    243       Helical; (Potential).
FT   TRANSMEM    284    304       Helical; (Potential).
FT   TRANSMEM    315    335       Helical; (Potential).
FT   TRANSMEM    340    360       Helical; (Potential).
FT   TRANSMEM    364    384       Helical; (Potential).
FT   TRANSMEM    395    415       Helical; (Potential).
FT   DOMAIN        3    427       PTS EIIC type-1.
FT   DOMAIN      438    519       PTS EIIB type-1.
FT   DOMAIN      560    664       PTS EIIA type-1.
FT   ACT_SITE    460    460       Phosphocysteine intermediate; for EIIB
FT                                activity (By similarity).
FT   ACT_SITE    612    612       Tele-phosphohistidine intermediate; for
FT                                EIIA activity (By similarity).
SQ   SEQUENCE   688 AA;  74416 MW;  11D5CCB25833DD21 CRC64;
     MFKKLFGQLQ RIGKALMLPV AILPAAGILL AFGNAMHNEQ LVEIAPWLKN DIIVMISSVM
     EAAGQVVFDN LPLLFAVGTA LGLAGGDGVA ALAALVGYLI MNATMGKVLH ITIDDIFSYA
     KGAKELSQAA KEPAHALVLG IPTLQTGVFG GIIMGALAAW CYNKFYNITL PPFLGFFAGK
     RFVPIVTSVV AIATGVLLSF AWPPIQDGLN SLSNFLLNKN LTLTTFIFGI IERSLIPFGL
     HHIFYSPFWF EFGSYTNHAG ELVRGDQRIW MAQLKDGVPF TAGAFTTGKY PFMMFGLPAA
     AFAIYKNARP ERKKVVGGLM LSAGLTAFLT GITEPLEFSF LFVAPVLYGI HVLLAGTSFL
     VMHLLGVKIG MTFSGGFIDY ILYGLLNWDR SHALLVIPVG IVYAIVYYFL FDFAIRKFKL
     KTPGREDEET EIRNSSVAKL PFDVLDAMGG KENIKHLDAC ITRLRVEVVD KSKVDVAGIK
     ALGASGVLEV GNNMQAIFGP KSDQIKHDMA KIMSGEITKP SETTVTEEMS DEPVHVEALG
     TTDIYAPGVG QIIPLSEVPD QVFAGKMMGD GIGFIPEKGE IVAPFDGTVK TIFPTKHAIG
     LESESGVEVL IHIGIDTVKL NGEGFESLIN VDEKVTQGQP LMKVNLAYLK AHAPSIVTPM
     IITNLENKEL VIEDVQDADP GKLIMTVK
//
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