ID A6UB91_SINMW Unreviewed; 582 AA.
AC A6UB91;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:ABR60921.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:ABR60921.1};
GN OrderedLocusNames=Smed_2088 {ECO:0000313|EMBL:ABR60921.1};
OS Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=366394 {ECO:0000313|EMBL:ABR60921.1, ECO:0000313|Proteomes:UP000001108};
RN [1] {ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|Proteomes:UP000001108};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA Richardson P.;
RT "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR60921.1, ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|EMBL:ABR60921.1,
RC ECO:0000313|Proteomes:UP000001108};
RX PubMed=21304680; DOI=10.4056/sigs.43526;
RA Reeve W., Chain P., O'Hara G., Ardley J., Nandesena K., Brau L., Tiwari R.,
RA Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA Hauser L., Chang Y.J., Ivanova N., Mavromatis K., Markowitz V.,
RA Kyrpides N., Gollagher M., Yates R., Dilworth M., Howieson J.;
RT "Complete genome sequence of the Medicago microsymbiont Ensifer
RT (Sinorhizobium) medicae strain WSM419.";
RL Stand. Genomic Sci. 2:77-86(2010).
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DR EMBL; CP000738; ABR60921.1; -; Genomic_DNA.
DR RefSeq; WP_011976218.1; NC_009636.1.
DR RefSeq; YP_001327756.1; NC_009636.1.
DR AlphaFoldDB; A6UB91; -.
DR STRING; 366394.Smed_2088; -.
DR GeneID; 61612997; -.
DR KEGG; smd:Smed_2088; -.
DR PATRIC; fig|366394.8.peg.5246; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_2_5; -.
DR OrthoDB; 9789078at2; -.
DR Proteomes; UP000001108; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:ABR60921.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transferase {ECO:0000313|EMBL:ABR60921.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 88..196
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 260..558
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 582 AA; 62749 MW; 74CB45D56DEF4A37 CRC64;
MSFLSRIMVL KSKAHFSAGG DHRTTDGGLN VTFEGTRKRS ASRAKSRVAI MIASFGVVYA
VIGGRLVQYG LAQPETVSSI GRADTLMASR PDILDRNGEV LATDIRTVSL YAEPHKIVDA
DEAVERLATV LPDLNAREIY NKLKSDSRFQ WLRRQLTPKQ QSEILALGIP GIGFRPEKRR
FYPGGPTAAH ILGHVNIDNR GVAGMERYID EQGLADLAAI GMTSDAKLEP VRLSIDVRVQ
NIVRDVVDSG MKNYEAIAAG AVVLDVHTGE VLAMASVPDY DPNRPAEGAE EGWMNRMSNG
TFEMGSTFKT FTIAMGLDSG KVTLNDSFDA TRPIRIGGFT IKDFHGKRRV LTVPEIFQYS
SNIGTAKIAD LIGIPGHKEF LTRMGLLTRL PTELPEVKSP SQPREWKKIN SITISFGHGV
STTPLQTAVA GAALVNGGKL IPPSFLPRSE EEASELASAV VKKSTSDDMR YLLRRNGIAG
SGKRALVPGF NVGGKTGTAD KVVNGRYASD LNFNAFLAAF PIDNPKYMVL TFIDAPKTGE
GGGRTAGSNA APMVRDIISR SAPLLGVEPK FGEDGSALLV SY
//
