ID A6UFJ6_SINMW Unreviewed; 1089 AA.
AC A6UFJ6;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Adenylyl cyclase class-3/4/guanylyl cyclase {ECO:0000313|EMBL:ABR62426.1};
GN OrderedLocusNames=Smed_3612 {ECO:0000313|EMBL:ABR62426.1};
OS Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OG Plasmid pSMED01 {ECO:0000313|EMBL:ABR62426.1,
OG ECO:0000313|Proteomes:UP000001108}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=366394 {ECO:0000313|EMBL:ABR62426.1, ECO:0000313|Proteomes:UP000001108};
RN [1] {ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|Proteomes:UP000001108};
RC PLASMID=Plasmid pSMED01 {ECO:0000313|Proteomes:UP000001108};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA Richardson P.;
RT "Complete sequence of Sinorhizobium medicae WSM419 plasmid pSMED01.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR62426.1, ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|EMBL:ABR62426.1,
RC ECO:0000313|Proteomes:UP000001108};
RC PLASMID=Plasmid pSMED01 {ECO:0000313|Proteomes:UP000001108};
RX PubMed=21304680; DOI=10.4056/sigs.43526;
RA Reeve W., Chain P., O'Hara G., Ardley J., Nandesena K., Brau L., Tiwari R.,
RA Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA Hauser L., Chang Y.J., Ivanova N., Mavromatis K., Markowitz V.,
RA Kyrpides N., Gollagher M., Yates R., Dilworth M., Howieson J.;
RT "Complete genome sequence of the Medicago microsymbiont Ensifer
RT (Sinorhizobium) medicae strain WSM419.";
RL Stand. Genomic Sci. 2:77-86(2010).
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DR EMBL; CP000739; ABR62426.1; -; Genomic_DNA.
DR RefSeq; WP_011969249.1; NC_009620.1.
DR RefSeq; YP_001312359.1; NC_009620.1.
DR AlphaFoldDB; A6UFJ6; -.
DR KEGG; smd:Smed_3612; -.
DR PATRIC; fig|366394.8.peg.39; -.
DR HOGENOM; CLU_004435_0_1_5; -.
DR OrthoDB; 9785312at2; -.
DR Proteomes; UP000001108; Plasmid pSMED01.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR025874; DZR.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF12773; DZR; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plasmid {ECO:0000313|EMBL:ABR62426.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 86..218
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1089 AA; 117972 MW; BD7C221666BB79F9 CRC64;
MNCAGCGLEI QGGFAFCPKC GMRQPKSCLG CGYPCPSDSA FCPKCGAPTN DAGAEGKPTS
RAASALTVKI KQPALPAVDA DRRTITILFA DLSGFTALSE QIDPELMQAL QNELFEELTE
AVQSFGGFVD KFIGDALLAL FGAPIAHEED PERALRAALD MVERASRMGE RWQARAGAPP
ILHIGVNTGP VVTGGFGAGS AKSYSVTGDT VNTAQRLQSM ASPSEVLVGP LTQRLTRHAF
VFETLGETML RGKTGSIPVY RLKGLREAAR PARGLEALGL STPLIGRKAE LERMFASLDL
ACRGSAQLVR LVGEAGIGKS RLVNEFIARI GDEQRFAAVA IRQAACSPLG EQSYGTLAAV
VRSAAGMRQG GPVAETKARL SDLLGELGLN GDEAVSLTPL LLHVVGLGGP EGALRHVQPE
QLRRQIFFAI RTIFERRLAL GPLLIVVEDL HWADAVSLEA LRFLMDRLEQ QRLIMVFTHR
PTFDMEQLDS RRISHTTLRL APLDDNGGRK LLASLFGEKW DQTLNSLGSR ILDRAGGNPL
FIEEIVRGFI EDGILERDGL HWRAASSEAA VEIPASIQAI LLARADRLPP EARRLAQEAA
VLGPRFDATL LAAISAHPKN IETGLDILCD AEIIEEVAAG GSIASRSYRF TQALLQNVIY
QNLLLQRRTE MHGQVGMALE QSCGQDPERL EDLLLLGHHF SLSPNRAKGA RYLRSAGDRA
RAVYANDDAI RHYQQALTAL ADEPEPVELR LSLRERIADL CGTTGRREAA HEHYRTVLVA
RRATGDRAGA ARILRKLGRL LWQAGKRTHA EAHYAEAALL LEGTDARIEQ ALLLQERGRL
AFRIGEHSNA IKWAEKALEQ AESLPVDADE GTRLEAAHAT AEALNTKGVA LARLERCREA
VIEVEQSVNV AEAAGLLSAA CRGYTNLGVL YTVIDPARAI QVCRRGLEVA RRIGDLGFQA
RLLANLAVVS CTFTDRCGGE GVPAAEKAIE LDRALDQREH LPVPLIVLGQ IHQCHGEPEL
AARCYNEALE VARETGEPQM LFPCYDGLAT LSLDVGDMGE AERYFSLAQD VCNQHGLDPE
GLVVLPFLD
//
