ID A6UH30_SINMW Unreviewed; 442 AA.
AC A6UH30;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=3-hydroxybutyryl-CoA epimerase {ECO:0000313|EMBL:ABR62960.1};
DE EC=5.1.2.3 {ECO:0000313|EMBL:ABR62960.1};
GN OrderedLocusNames=Smed_4155 {ECO:0000313|EMBL:ABR62960.1};
OS Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OG Plasmid pSMED01 {ECO:0000313|EMBL:ABR62960.1,
OG ECO:0000313|Proteomes:UP000001108}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=366394 {ECO:0000313|EMBL:ABR62960.1, ECO:0000313|Proteomes:UP000001108};
RN [1] {ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|Proteomes:UP000001108};
RC PLASMID=Plasmid pSMED01 {ECO:0000313|Proteomes:UP000001108};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA Richardson P.;
RT "Complete sequence of Sinorhizobium medicae WSM419 plasmid pSMED01.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR62960.1, ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|EMBL:ABR62960.1,
RC ECO:0000313|Proteomes:UP000001108};
RC PLASMID=Plasmid pSMED01 {ECO:0000313|Proteomes:UP000001108};
RX PubMed=21304680; DOI=10.4056/sigs.43526;
RA Reeve W., Chain P., O'Hara G., Ardley J., Nandesena K., Brau L., Tiwari R.,
RA Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA Hauser L., Chang Y.J., Ivanova N., Mavromatis K., Markowitz V.,
RA Kyrpides N., Gollagher M., Yates R., Dilworth M., Howieson J.;
RT "Complete genome sequence of the Medicago microsymbiont Ensifer
RT (Sinorhizobium) medicae strain WSM419.";
RL Stand. Genomic Sci. 2:77-86(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000739; ABR62960.1; -; Genomic_DNA.
DR RefSeq; WP_011969782.1; NC_009620.1.
DR RefSeq; YP_001312893.1; NC_009620.1.
DR AlphaFoldDB; A6UH30; -.
DR KEGG; smd:Smed_4155; -.
DR PATRIC; fig|366394.8.peg.611; -.
DR HOGENOM; CLU_009834_2_0_5; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000001108; Plasmid pSMED01.
DR GO; GO:0008692; F:3-hydroxybutyryl-CoA epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:ABR62960.1};
KW Plasmid {ECO:0000313|EMBL:ABR62960.1}.
FT DOMAIN 47..222
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 227..318
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 442 AA; 47134 MW; 82834545CC510005 CRC64;
MALNIVHRGG VALATTGNPL RHVFRAERVA RHAPELAGVE PRPIRSAAVI GGGTMGTGIA
AALCNAGLPL VIVERDEAAR EGAVARLRAI FDGAVKRRRI SAGLAAERLA RVTGATDYAV
LAEADLIIEA VFEDLDVKRD VFRKVAAACR HDAVLATNTS YLNPERIADG IASPERFLGL
HFFSPAQVMK LLEIVPTGAT APEALATGFA LARMLNKIPV RAGISDGFIG NRILKVMRGQ
AERLLVTGAS PSAVDAAMRA FGLPMGPFEA QDLGGLDIAA FQRRAARARG LPVFAPVSDR
LCAIARFGQK SGGGWYDYVP GHRTPLPSEA VARLVEEEAQ GWPRLDWDEA SIIDCILWPM
VNEAARIVED GTALRPSDID LVEIHGYGFP RWRGGLMHHA QAQGLDRIVA ALGAFAEKGL
ADPPSTLLVR AAAQGRFSEA LR
//
