ID A6UMQ0_SINMW Unreviewed; 307 AA.
AC A6UMQ0;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Homocysteine S-methyltransferase {ECO:0000313|EMBL:ABR64930.1};
GN OrderedLocusNames=Smed_6335 {ECO:0000313|EMBL:ABR64930.1};
OS Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OG Plasmid pSMED03 {ECO:0000313|EMBL:ABR64930.1,
OG ECO:0000313|Proteomes:UP000001108}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=366394 {ECO:0000313|EMBL:ABR64930.1, ECO:0000313|Proteomes:UP000001108};
RN [1] {ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|Proteomes:UP000001108};
RC PLASMID=Plasmid pSMED03 {ECO:0000313|Proteomes:UP000001108};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA Richardson P.;
RT "Complete sequence of Sinorhizobium medicae WSM419 plasmid pSMED03.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR64930.1, ECO:0000313|Proteomes:UP000001108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419 {ECO:0000313|EMBL:ABR64930.1,
RC ECO:0000313|Proteomes:UP000001108};
RC PLASMID=Plasmid pSMED03 {ECO:0000313|Proteomes:UP000001108};
RX PubMed=21304680; DOI=10.4056/sigs.43526;
RA Reeve W., Chain P., O'Hara G., Ardley J., Nandesena K., Brau L., Tiwari R.,
RA Malfatti S., Kiss H., Lapidus A., Copeland A., Nolan M., Land M.,
RA Hauser L., Chang Y.J., Ivanova N., Mavromatis K., Markowitz V.,
RA Kyrpides N., Gollagher M., Yates R., Dilworth M., Howieson J.;
RT "Complete genome sequence of the Medicago microsymbiont Ensifer
RT (Sinorhizobium) medicae strain WSM419.";
RL Stand. Genomic Sci. 2:77-86(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU00333};
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DR EMBL; CP000741; ABR64930.1; -; Genomic_DNA.
DR RefSeq; WP_011971140.1; NC_009622.1.
DR RefSeq; YP_001314863.1; NC_009622.1.
DR AlphaFoldDB; A6UMQ0; -.
DR KEGG; smd:Smed_6335; -.
DR PATRIC; fig|366394.8.peg.2859; -.
DR HOGENOM; CLU_062282_0_0_5; -.
DR OrthoDB; 9803687at2; -.
DR Proteomes; UP000001108; Plasmid pSMED03.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.330; Homocysteine-binding-like domain; 1.
DR InterPro; IPR003726; HCY_dom.
DR InterPro; IPR036589; HCY_dom_sf.
DR PANTHER; PTHR11103:SF18; HOMOCYSTEINE S-METHYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR11103; SLR1189 PROTEIN; 1.
DR Pfam; PF02574; S-methyl_trans; 1.
DR SUPFAM; SSF82282; Homocysteine S-methyltransferase; 1.
DR PROSITE; PS50970; HCY; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00333};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Plasmid {ECO:0000313|EMBL:ABR64930.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00333}; Zinc {ECO:0000256|PROSITE-ProRule:PRU00333}.
FT DOMAIN 2..306
FT /note="Hcy-binding"
FT /evidence="ECO:0000259|PROSITE:PS50970"
FT BINDING 224
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 291
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
FT BINDING 292
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00333"
SQ SEQUENCE 307 AA; 33444 MW; B46C0EC9C57A47B8 CRC64;
MGILDRLFSS PDPFISDGGM ETDLIFHEGA EMPLFASFVL LDSPEGCEML RRYAVSYFDL
AQVASRGFVM GTPTWRANGG WGPKLGLDDA GIRDVNRRAI AFARDLRSAH PWRDHILIEG
VLGPAGDGYA PEQLLTPTEA ARLHSAQLET FAEEDVDIAS AFTITHPGEA IGMVNRARDL
GLPFALSFTV ETDGRLPTGQ DLDCALDEVE AATGGYVRYY GINCAHPEHF GEQLPSRWLN
RIGVVRPNAS RRSHAELDEA TELDDGDPQE FGALYAEMAE KLPRLRVVGG CCGSDMRHIK
ALIAAGV
//
