GenomeNet

Database: UniProt
Entry: A6UNY0
LinkDB: A6UNY0
Original site: A6UNY0 
ID   DNLI_METVS              Reviewed;         573 AA.
AC   A6UNY0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-OCT-2017, entry version 71.
DE   RecName: Full=DNA ligase {ECO:0000255|HAMAP-Rule:MF_00407};
DE            EC=6.5.1.1 {ECO:0000255|HAMAP-Rule:MF_00407};
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP] {ECO:0000255|HAMAP-Rule:MF_00407};
GN   Name=lig {ECO:0000255|HAMAP-Rule:MF_00407};
GN   OrderedLocusNames=Mevan_0293;
OS   Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 /
OS   OCM 148 / SB).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=406327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus vannielii SB.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00407};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
DR   EMBL; CP000742; ABR54202.1; -; Genomic_DNA.
DR   RefSeq; WP_011972105.1; NC_009634.1.
DR   ProteinModelPortal; A6UNY0; -.
DR   SMR; A6UNY0; -.
DR   STRING; 406327.Mevan_0293; -.
DR   EnsemblBacteria; ABR54202; ABR54202; Mevan_0293.
DR   GeneID; 5325495; -.
DR   KEGG; mvn:Mevan_0293; -.
DR   eggNOG; arCOG01347; Archaea.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000036008; -.
DR   KO; K10747; -.
DR   OMA; ETVCNIG; -.
DR   OrthoDB; POG093Z03L0; -.
DR   Proteomes; UP000001107; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   HAMAP; MF_00407; DNA_ligase; 1.
DR   InterPro; IPR022865; DNA_ligae_ATP-dep_bac/arc.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA recombination; DNA repair; DNA replication; Ligase; Magnesium;
KW   Metal-binding; Nucleotide-binding.
FT   CHAIN         1    573       DNA ligase.
FT                                /FTId=PRO_0000365253.
FT   ACT_SITE    252    252       N6-AMP-lysine intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     250    250       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     257    257       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     272    272       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     301    301       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     342    342       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     432    432       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     438    438       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
SQ   SEQUENCE   573 AA;  65996 MW;  3FD171BEDDFFA183 CRC64;
     MLFNEFCKII EKIENTPKRL EKIDYFVEII DFVKNHGKPE NLKEICQVSI GRVFAEYENR
     EIGIGPNLLI EAIKTTGISE NDLNLKIKET GDIGISVEHL SSKIKQISLF NEPLTFEEVY
     STIKKLSTIE GTSSQKKKIR IISNLLIIAN PIESRYISRL ILEDMRIGMN IPTILAAFSN
     YFGIEKEKIE KVYAVTNDIG LIGKKLLENS NFEEDPELNL TVFRPIKPML AQLTPSIEEA
     VIEMKNPQFE TKYDGARVQV HKSNGEVKIY SRRLEDITNS VPELVLEIKN LEVDNVILEG
     ECVAMNLENG KPRPFQDILR RFRRKYDIDK MTEEVSLRIY FFDILYHNKG LIDLPLFERR
     NILENIFGTN NWDLELKKIE NEIKSNKMLF TSFKVSSTDL KIAKEFFKWS LSIGHEGIMV
     KNLNAIYTPG SRVKTMCKIK QTLENLDVVV TRAKIGMGKR KDWYGSYEIS VKGDDESLHV
     IGNVGSGLTE EDLEKLTKIA NEIKIEDLGG EVILEPKIVL EVTYEEIQTS EKYEMGYALR
     FPRVVGIRED KSINDINSLD DVKKIYEIER KRK
//
DBGET integrated database retrieval system