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Database: UniProt
Entry: A6UUU2
LinkDB: A6UUU2
Original site: A6UUU2 
ID   ILVD_META3              Reviewed;         550 AA.
AC   A6UUU2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   19-FEB-2014, entry version 46.
DE   RecName: Full=Dihydroxy-acid dehydratase;
DE            Short=DAD;
DE            EC=4.2.1.9;
GN   Name=ilvD; OrderedLocusNames=Maeo_0680;
OS   Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=419665;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nankai-3 / ATCC BAA-1280;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC       oxobutanoate + H(2)O.
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 3/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 3/4.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family.
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DR   EMBL; CP000743; ABR56264.1; -; Genomic_DNA.
DR   RefSeq; YP_001324876.1; NC_009635.1.
DR   ProteinModelPortal; A6UUU2; -.
DR   STRING; 419665.Maeo_0680; -.
DR   EnsemblBacteria; ABR56264; ABR56264; Maeo_0680.
DR   GeneID; 5327023; -.
DR   KEGG; mae:Maeo_0680; -.
DR   eggNOG; COG0129; -.
DR   HOGENOM; HOG000173155; -.
DR   KO; K01687; -.
DR   OMA; IPGHVHL; -.
DR   ProtClustDB; PRK00911; -.
DR   BioCyc; MAEO419665:GHVZ-683-MONOMER; -.
DR   UniPathway; UPA00047; UER00057.
DR   UniPathway; UPA00049; UER00061.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00012; IlvD; 1.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR004404; DihydroxyA_deHydtase.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   PANTHER; PTHR21000; PTHR21000; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR00110; ilvD; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Amino-acid biosynthesis;
KW   Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW   Iron-sulfur; Lyase; Metal-binding.
FT   CHAIN         1    550       Dihydroxy-acid dehydratase.
FT                                /FTId=PRO_1000001003.
FT   METAL       119    119       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       191    191       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   550 AA;  58996 MW;  1F55E52DE004DB91 CRC64;
     MISDNLKKGV SRAPNRSLLK ACGYTDEEIE KPFIGIVNSF TEVVPGHIHL NTLAEAAKKG
     VYANGGTPFE FNTMAVCDGI AMGHEGMRYS LPSREIIADT VESMAKAHGF DGLVLIPSCD
     KIVPGMIMGA LRLNIPFIVI TGGPMQPGEL HGKKYDLISV FEGVGEYNVG KITKEELMEI
     ETCACPGAGS CAGLFTANSM ACLTETLGLS LPMCATTHAT DAEKVRIAKR SGMKIVDLVK
     EDIKPTDLLT KESFENAILV DLALGGSSNT TLHIPALAYE IAPEFITLDD FDRLCDEVPH
     IASLRPGGDH FISDLHRAGG IPAVLKILEQ KIRDANTVSG KSIKEIINEV KYIDYNIIRP
     VDKPVHETAG LRILKGNIAP DGCVVKISAV NPKMYKHEGP ARVFNSEEET IDAILGGDIK
     EGDVVVIRYE GPAGGPGMRE MLSPTSAICG MGLDDSVALI TDGRFSGGSR GPCIGHISPE
     AMAGGPIAII EEGDIIAIDM MAKEINLKIS EEEIKERLAN WKKPEIKVKK GYISRYAKLV
     SSANEGAVLK
//
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