ID ILVD_META3 Reviewed; 550 AA.
AC A6UUU2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 29-MAY-2013, entry version 44.
DE RecName: Full=Dihydroxy-acid dehydratase;
DE Short=DAD;
DE EC=4.2.1.9;
GN Name=ilvD; OrderedLocusNames=Maeo_0680;
OS Methanococcus aeolicus (strain Nankai-3 / ATCC BAA-1280).
OC Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nankai-3 / ATCC BAA-1280;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC oxobutanoate + H(2)O.
CC -!- COFACTOR: Binds 1 4Fe-4S cluster (Potential).
CC -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC isoleucine from 2-oxobutanoate: step 3/4.
CC -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC from pyruvate: step 3/4.
CC -!- SIMILARITY: Belongs to the IlvD/Edd family.
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DR EMBL; CP000743; ABR56264.1; -; Genomic_DNA.
DR RefSeq; YP_001324876.1; NC_009635.1.
DR ProteinModelPortal; A6UUU2; -.
DR STRING; 419665.Maeo_0680; -.
DR EnsemblBacteria; ABR56264; ABR56264; Maeo_0680.
DR GeneID; 5327023; -.
DR KEGG; mae:Maeo_0680; -.
DR eggNOG; COG0129; -.
DR HOGENOM; HOG000173155; -.
DR KO; K01687; -.
DR OMA; QGRNMAG; -.
DR ProtClustDB; PRK00911; -.
DR BioCyc; MAEO419665:GHVZ-683-MONOMER; -.
DR UniPathway; UPA00047; UER00057.
DR UniPathway; UPA00049; UER00061.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:HAMAP.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00012; IlvD; 1; -.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR004404; DihydroxyA_deHydtase.
DR InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR PANTHER; PTHR21000; PTHR21000; 1.
DR Pfam; PF00920; ILVD_EDD; 1.
DR SUPFAM; SSF52016; Aconitase/3IPM_dehydase_swvl; 1.
DR TIGRFAMs; TIGR00110; ilvD; 1.
DR PROSITE; PS00886; ILVD_EDD_1; 1.
DR PROSITE; PS00887; ILVD_EDD_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Amino-acid biosynthesis;
KW Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW Iron-sulfur; Lyase; Metal-binding.
FT CHAIN 1 550 Dihydroxy-acid dehydratase.
FT /FTId=PRO_1000001003.
FT METAL 119 119 Iron-sulfur (4Fe-4S) (Potential).
FT METAL 191 191 Iron-sulfur (4Fe-4S) (Potential).
SQ SEQUENCE 550 AA; 58996 MW; 1F55E52DE004DB91 CRC64;
MISDNLKKGV SRAPNRSLLK ACGYTDEEIE KPFIGIVNSF TEVVPGHIHL NTLAEAAKKG
VYANGGTPFE FNTMAVCDGI AMGHEGMRYS LPSREIIADT VESMAKAHGF DGLVLIPSCD
KIVPGMIMGA LRLNIPFIVI TGGPMQPGEL HGKKYDLISV FEGVGEYNVG KITKEELMEI
ETCACPGAGS CAGLFTANSM ACLTETLGLS LPMCATTHAT DAEKVRIAKR SGMKIVDLVK
EDIKPTDLLT KESFENAILV DLALGGSSNT TLHIPALAYE IAPEFITLDD FDRLCDEVPH
IASLRPGGDH FISDLHRAGG IPAVLKILEQ KIRDANTVSG KSIKEIINEV KYIDYNIIRP
VDKPVHETAG LRILKGNIAP DGCVVKISAV NPKMYKHEGP ARVFNSEEET IDAILGGDIK
EGDVVVIRYE GPAGGPGMRE MLSPTSAICG MGLDDSVALI TDGRFSGGSR GPCIGHISPE
AMAGGPIAII EEGDIIAIDM MAKEINLKIS EEEIKERLAN WKKPEIKVKK GYISRYAKLV
SSANEGAVLK
//
