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Database: UniProt
Entry: A6UWH2_META3
LinkDB: A6UWH2_META3
Original site: A6UWH2_META3 
ID   A6UWH2_META3            Unreviewed;       552 AA.
AC   A6UWH2;
DT   21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT   21-AUG-2007, sequence version 1.
DT   25-OCT-2017, entry version 53.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   OrderedLocusNames=Maeo_1268 {ECO:0000313|EMBL:ABR56844.1};
OS   Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS   Nankai-3).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=419665 {ECO:0000313|EMBL:ABR56844.1, ECO:0000313|Proteomes:UP000001106};
RN   [1] {ECO:0000313|EMBL:ABR56844.1, ECO:0000313|Proteomes:UP000001106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3
RC   {ECO:0000313|Proteomes:UP000001106};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT   "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP000743; ABR56844.1; -; Genomic_DNA.
DR   RefSeq; WP_011973976.1; NC_009635.1.
DR   ProteinModelPortal; A6UWH2; -.
DR   STRING; 419665.Maeo_1268; -.
DR   EnsemblBacteria; ABR56844; ABR56844; Maeo_1268.
DR   GeneID; 5327592; -.
DR   KEGG; mae:Maeo_1268; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   HOGENOM; HOG000225809; -.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000001106; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001106};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000001106};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:ABR56844.1}.
FT   DOMAIN        5    271       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      318    443       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       150    150       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     260    260       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     274    274       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   552 AA;  60711 MW;  E7E372EB7CB3A671 CRC64;
     MEAEKKLFLK ALKEKFDEDP KEKYTKFYTY GGWKQSKRKT EFVEAAKDIA DKRGGMPGYN
     PDIGVPLGQR KMMSYKLSGT DDYVEGDDLH FMNNAAIQQL HDDIRRTVIV GMDTGHMVLE
     KRLGVEVTPE TINEYMETIN HALPGGAVVQ EHMVEVDPAL AWDSYAKIFT GDDELADELD
     KRVLVDINKL FPEEQAEELK AAIGKKTYQI SRVPTLVGRV CDGGTIARWS AMQIGMSFIT
     AYKLCAGEAA IADFSYAAKH ADVIGMGTAL PARRSRGANE PGGIPFGILC DVVQTTRISD
     DPVEQSLEVV ATGAMLYDQI WLGAYMSGGV GFTQYATAAY TDDILDDFCY YGLDYVEKKF
     GRCGTKATMD VVEDIATEVT LYSLEQYDEY PTLLEDHFGG SQRAAVAAAA AGVSVCMATG
     NSNAGVNGWY LSQIMHKEYH SRLGFYGYDL QDQCGASNSL SIRNDESSPL ELRGPNYPNY
     AMNVGHQGEY AGITQAAHSA RGDAFAMNPL IKVAFADPSL IFDFARPRKC CARGALREFE
     VAGERDPILP AK
//
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