ID A6UWY1_META3 Unreviewed; 469 AA.
AC A6UWY1;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Nitrogenase molybdenum-iron protein alpha chain {ECO:0000256|ARBA:ARBA00017663};
DE AltName: Full=Dinitrogenase {ECO:0000256|ARBA:ARBA00031726};
GN OrderedLocusNames=Maeo_1427 {ECO:0000313|EMBL:ABR57003.1};
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665 {ECO:0000313|EMBL:ABR57003.1, ECO:0000313|Proteomes:UP000001106};
RN [1] {ECO:0000313|EMBL:ABR57003.1, ECO:0000313|Proteomes:UP000001106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3
RC {ECO:0000313|Proteomes:UP000001106};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This molybdenum-iron protein is part of the nitrogenase
CC complex that catalyzes the key enzymatic reactions in nitrogen
CC fixation. {ECO:0000256|ARBA:ARBA00002621}.
CC -!- COFACTOR:
CC Name=[7Fe-Mo-9S-C-homocitryl] cluster; Xref=ChEBI:CHEBI:30409;
CC Evidence={ECO:0000256|ARBA:ARBA00001969};
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains. Forms complex with
CC the iron protein (nitrogenase component 2).
CC {ECO:0000256|ARBA:ARBA00011462}.
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DR EMBL; CP000743; ABR57003.1; -; Genomic_DNA.
DR RefSeq; WP_011974135.1; NC_009635.1.
DR AlphaFoldDB; A6UWY1; -.
DR STRING; 419665.Maeo_1427; -.
DR GeneID; 5326533; -.
DR KEGG; mae:Maeo_1427; -.
DR eggNOG; arCOG00598; Archaea.
DR HOGENOM; CLU_025876_1_1_2; -.
DR OrthoDB; 72973at2157; -.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016163; F:nitrogenase activity; IEA:InterPro.
DR CDD; cd01967; Nitrogenase_MoFe_alpha_like; 1.
DR Gene3D; 3.40.50.12380; Nitrogenase MoFe cofactor biosynthesis protein NifE, C-terminal; 1.
DR Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 1.
DR InterPro; IPR000510; Nase/OxRdtase_comp1.
DR InterPro; IPR010143; Nase_comp1_asu.
DR PANTHER; PTHR43457; NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN; 1.
DR PANTHER; PTHR43457:SF1; NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN; 1.
DR Pfam; PF00148; Oxidored_nitro; 1.
DR SUPFAM; SSF53807; Helical backbone' metal receptor; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABR57003.1}.
FT DOMAIN 60..460
FT /note="Nitrogenase/oxidoreductase component 1"
FT /evidence="ECO:0000259|Pfam:PF00148"
SQ SEQUENCE 469 AA; 52893 MW; E4230C429821DC6B CRC64;
MEKTQNAGDT NIISDINANS TNKNVKGRID RIGHCITNDN NTLPACAEFT QPGDFSERSC
TFHGSKIIIN SHIKNVIHLI HSPASCAYYS WDYRPDTYSF CFTTDIKEED VVFGGEKKLY
DAILKICEEF NPDAIFVYET CQTALIGDDI SAVVKEVKKK LKNTNHKNKD TPILAFECAG
FKGKTQNKGH MIANKKLFEL IATKEVEEVL EQPPTPYDVN IIGDFSTGSS NSIEQIFNKM
GVRVLCSFTG NATIDRIRIM DSAKLNIVHC MKSSIQFANM MEKVYEVPYI VSNFFGIQNC
CDALENIGKI LDIDKKVVDN TIDYYLNKNE KELEYYKKEL KGKKVFICHG AQRALNYMGP
TMEELEMEVV GVATYFANKE NYEKIVKQLP KGAVIIDNPN TYELENAIID CKPDIFISDS
KTKELVHKLG IPYINGRAPS TVYIGFDGFV NFAKDVYGAI NSNIWKLVK
//
