ID A6V8N2_PSEA7 Unreviewed; 644 AA.
AC A6V8N2;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Serine protease {ECO:0000256|RuleBase:RU004296};
DE EC=3.4.21.- {ECO:0000256|RuleBase:RU004296};
GN OrderedLocusNames=PSPA7_4063 {ECO:0000313|EMBL:ABR83370.1};
OS Pseudomonas aeruginosa (strain PA7).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=381754 {ECO:0000313|EMBL:ABR83370.1, ECO:0000313|Proteomes:UP000001582};
RN [1] {ECO:0000313|EMBL:ABR83370.1, ECO:0000313|Proteomes:UP000001582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7 {ECO:0000313|EMBL:ABR83370.1,
RC ECO:0000313|Proteomes:UP000001582};
RA Dodson R.J., Harkins D., Paulsen I.T.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR83370.1, ECO:0000313|Proteomes:UP000001582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7 {ECO:0000313|EMBL:ABR83370.1,
RC ECO:0000313|Proteomes:UP000001582};
RX PubMed=20107499; DOI=10.1371/journal.pone.0008842;
RA Roy P.H., Tetu S.G., Larouche A., Elbourne L., Tremblay S., Ren Q.,
RA Dodson R., Harkins D., Shay R., Watkins K., Mahamoud Y., Paulsen I.T.;
RT "Complete genome sequence of the multiresistant taxonomic outlier
RT Pseudomonas aeruginosa PA7.";
RL PLoS ONE 5:E8842-E8842(2010).
CC -!- SIMILARITY: Belongs to the peptidase S1B family.
CC {ECO:0000256|ARBA:ARBA00008764, ECO:0000256|RuleBase:RU004296}.
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DR EMBL; CP000744; ABR83370.1; -; Genomic_DNA.
DR AlphaFoldDB; A6V8N2; -.
DR KEGG; pap:PSPA7_4063; -.
DR HOGENOM; CLU_016161_0_0_6; -.
DR Proteomes; UP000001582; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR040255; Non-specific_endonuclease.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR008256; Peptidase_S1B.
DR PANTHER; PTHR13966:SF5; ENDONUCLEASE G, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13966; ENDONUCLEASE RELATED; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00839; V8PROTEASE.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000313|EMBL:ABR83370.1};
KW Hydrolase {ECO:0000256|RuleBase:RU004296};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR640255-2};
KW Nuclease {ECO:0000313|EMBL:ABR83370.1};
KW Protease {ECO:0000256|RuleBase:RU004296};
KW Serine protease {ECO:0000256|RuleBase:RU004296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 398..606
FT /note="DNA/RNA non-specific endonuclease"
FT /evidence="ECO:0000259|SMART:SM00892"
FT DOMAIN 399..606
FT /note="Extracellular Endonuclease subunit A"
FT /evidence="ECO:0000259|SMART:SM00477"
FT ACT_SITE 461
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR640255-1"
FT BINDING 498
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR640255-2"
SQ SEQUENCE 644 AA; 71141 MW; 3FA69939264FE85A CRC64;
MAMRKRNARR ATPEELRVCS VLKEKDTREE LAELAARGEW SNVPAYNASR GQIAEHLGKS
LSPESDASFF DSRRFSEAIV LLKSRPVLLV KNGIFDEAPL AGLEQRLKRH RAALATPIRS
VGRLELIDHD SMDWCGTGWR IEDDLIVTNR HVASLFAERQ GNLFRFRLNQ AGKQVRTRVD
FREEYRQPES DEHVIARVLW IAPDVSEAPD MAILQVVKGD LLPPPLSLAR RDAEPRQAVA
VVGYPARDSR NDAGAMEDIF GNIYDVKRFA PGEVVGLPGD AWYLTHDCST LGGNSGSAVL
SIDGGEVVGL HFGGQFRKTN YAVKASVIRS LLARRAWVPV GEAELKCGAP RFQEKKRSVA
DLAGRKGFDE AFLGPKAALP KPGKSHQVLP VGKGTRLDYL HFSVVMSASR RLPILTAVNI
DGALKRSLKR KDSWGFDPRI EAAAQVGHKD FYGPASFDKG HMVRREDPGW GDSDAVARQA
EDDTFVYTNA VPQVAQLNQR SWLSLEDYVL QNARSEGFRI SVFTGPVFRE DDPLFQGVQV
PLEFWKVVAM IDADSGELGV SAYLLGQEGM MPGEGFRYGA FKTYQVPLAK VEASADLRFS
SALRKADVLA GTPLEEALEA GRFIEINGPD DLLLGRPTPA GKRR
//