ID A6VCW2_PSEA7 Unreviewed; 942 AA.
AC A6VCW2;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 2.
DT 24-JAN-2024, entry version 86.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=PSPA7_5576 {ECO:0000313|EMBL:ABR86205.2};
OS Pseudomonas aeruginosa (strain PA7).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=381754 {ECO:0000313|EMBL:ABR86205.2, ECO:0000313|Proteomes:UP000001582};
RN [1] {ECO:0000313|EMBL:ABR86205.2, ECO:0000313|Proteomes:UP000001582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7 {ECO:0000313|EMBL:ABR86205.2,
RC ECO:0000313|Proteomes:UP000001582};
RA Dodson R.J., Harkins D., Paulsen I.T.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABR86205.2, ECO:0000313|Proteomes:UP000001582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7 {ECO:0000313|EMBL:ABR86205.2,
RC ECO:0000313|Proteomes:UP000001582};
RX PubMed=20107499; DOI=10.1371/journal.pone.0008842;
RA Roy P.H., Tetu S.G., Larouche A., Elbourne L., Tremblay S., Ren Q.,
RA Dodson R., Harkins D., Shay R., Watkins K., Mahamoud Y., Paulsen I.T.;
RT "Complete genome sequence of the multiresistant taxonomic outlier
RT Pseudomonas aeruginosa PA7.";
RL PLoS ONE 5:E8842-E8842(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000744; ABR86205.2; -; Genomic_DNA.
DR RefSeq; WP_033997462.1; NC_009656.1.
DR AlphaFoldDB; A6VCW2; -.
DR GeneID; 77223404; -.
DR KEGG; pap:PSPA7_5576; -.
DR HOGENOM; CLU_000445_105_0_6; -.
DR Proteomes; UP000001582; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16938; HATPase_ETR2_ERS2-EIN4-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 2.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 2.60.40.2380; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR InterPro; IPR011622; 7TMR_DISM_rcpt_extracell_dom2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR Pfam; PF07696; 7TMR-DISMED2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 2.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..942
FT /note="histidine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5020036191"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 421..641
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 659..781
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 809..928
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 713
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT MOD_RES 858
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 942 AA; 103821 MW; 420E5CB26745EFE8 CRC64;
MVRLRIAIGL LVSCLLLLLG PISPAVADDS GVSSVPLQTT ATTPSANQNW RVLRDESAQL
RIADVLQRKE QFRPLAKRSF IFPASTQAVW LQVQLPEQKA PSWLWIFAPR VQYLDYYLVQ
DGQLVRDQHT GESRPFQERP LPSRSYLFSL PVDGKPMTLY VRMTSNHPLM AWFDQIDEAG
LVGLEKPAYA FGMLLGGMLL LLMYNLIRFA YSRSASSLWL AAVHAALAVC AAANLGLVAF
WLPGLRFNQS LTADLGALGA AVSLLWFACS FFRGTAESRL NRLLQGEALL ILAVGAIIAF
TQQLWFSWLI YLLVILSSLS VPLVAAWHWY RGYQPARLIV AGMIVFNAGF MVFLPVLFGT
RQLDPGWLVL GVFSFATLAG LVLSVSLTER QRLIQQLNLQ QRTSEAAHTA ELQTKAEFLA
KISHEIRTPM NGVLGMTELL LGTPLSAKQR DYVQTIHSAG NELLTLINEI LDISKLESGQ
IELDEVQFDL NALIEDCLDI FRVKAEQQRI ELISFTQPQV PRVIGGDPTR LRQVVLSLLD
NAFKQTEEGE ILLVVALDEQ SGAPRLRIAV QDSGHPFDAK EREALLTAEL HSGDFLSASK
LGSHLGLIIA RQLVRLMGGE FGIQSGSSQG TTLSLTLPLD PQQLENPTAD LDGPLQGARL
LVVDDNETCR KVLLQQCSGW GLNVSAVSSG KEALAQLRTK AHLREYFDVV LLDQDMPGMT
GMQLAAKIKE DPNLNHDILL IMLTGISNAP SKIIARNAGI KRILAKPVAG YTLKATLADE
LAQRGVSGVT NYLHPAKEAQ APSLPSDFRI LVAEDNSIST KVIRGMLNKL NLQPDTASNG
QEALAAMKAT QYDLVLMDCE MPVLDGFSAT EQLRAWEAHE QRPHTPVVAL TAHILSEHKE
RARLVGMDGH MAKPVELSQL RELIAYWVGE RDRRRQGDAL PS
//
