ID A6WFD0_KINRD Unreviewed; 643 AA.
AC A6WFD0;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Thiamine pyrophosphate protein central region {ECO:0000313|EMBL:ABS05519.1};
GN OrderedLocusNames=Krad_4056 {ECO:0000313|EMBL:ABS05519.1};
OS Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14245 / SRS30216).
OC Bacteria; Actinomycetota; Actinomycetes; Kineosporiales; Kineosporiaceae;
OC Kineococcus.
OX NCBI_TaxID=266940 {ECO:0000313|EMBL:ABS05519.1, ECO:0000313|Proteomes:UP000001116};
RN [1] {ECO:0000313|Proteomes:UP000001116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-149 / DSM 14245 / SRS30216
RC {ECO:0000313|Proteomes:UP000001116};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Bagwell C.E., Shimkets L., Berry C.J.,
RA Fliermans C., Richardson P.;
RT "Complete sequence of chromosome of Kineococcus radiotolerans SRS30216.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CP000750; ABS05519.1; -; Genomic_DNA.
DR RefSeq; WP_012086193.1; NC_009664.2.
DR AlphaFoldDB; A6WFD0; -.
DR STRING; 266940.Krad_4056; -.
DR KEGG; kra:Krad_4056; -.
DR eggNOG; COG3962; Bacteria.
DR HOGENOM; CLU_013748_6_0_11; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000001116; Chromosome.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd02003; TPP_IolD; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001116};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 18..154
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 239..373
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 439..595
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 643 AA; 69063 MW; 37601064FD06B662 CRC64;
MSAVPPNPAV VTVRLTVSQA VVRFLQAQFS ERDGVRRPFF GGVFGIFGHG NVAGIGQALL
EAEEGALGDD WEPPAHLRYM TGRNEQAMVH AAVGYARQQD RLQTLAVTAS VGPGSTNMLT
GAALATVNRI PVLLLPADVF ATRVASPVLQ ELEQPYGYDV SVNDAFRPLS KFFDRVWRPE
QLPSALLGAM RVLTDPAETG AATICLPEDL QAEAWDFPVE LFRERTWRIA RPVPEKVAIA
EAADLIRSAK APLVVAGGGV VYSQATEALR AFVEATGIPV GQSQAGKGAI RYDHPLSLGA
VGSTGTTAAN EIAAEADVVI GIGTRYSDFT TGSRTAFQNP DVRFVNVNVA SLDAVKHAGL
PVQADAREAL EALTEALEGF STPDAYRERA ARLNREWDAV VDRFFHSGIG EAKGLLAQAE
VIGAVDEVAG DRDVVVCAAG SLPGDLHAMW RSRDPKQYHV EYGYSCMGYE IPGGIGVALA
APDRDVFITV GDGSFLMMPT ELVTAVQEGV KVIVVLLQNH GFASIGALSE QHGSQRYGTR
YRKRSESGRL EGEKLPVDLA ANVESLGIRT LRAGTRKELV AALQDAKASR ESTCVYVETD
LYSEAPDGGG WWDVPVSEVS HLESTRAART WYEGEKRTQR PLL
//
