ID A6ZVZ7_YEAS7 Unreviewed; 551 AA.
AC A6ZVZ7;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Thiamine metabolism-related protein {ECO:0000313|EMBL:EDN60889.1};
GN Name=THI21 {ECO:0000313|EMBL:EDN60889.1};
GN ORFNames=SCY_5474 {ECO:0000313|EMBL:EDN60889.1};
OS Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=307796 {ECO:0000313|EMBL:EDN60889.1, ECO:0000313|Proteomes:UP000007060};
RN [1] {ECO:0000313|EMBL:EDN60889.1, ECO:0000313|Proteomes:UP000007060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJM789 {ECO:0000313|EMBL:EDN60889.1,
RC ECO:0000313|Proteomes:UP000007060};
RX PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA Steinmetz L.M.;
RT "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT strain YJM789.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDN60889.1}.
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DR EMBL; AAFW02000135; EDN60889.1; -; Genomic_DNA.
DR AlphaFoldDB; A6ZVZ7; -.
DR HOGENOM; CLU_020520_2_1_1; -.
DR Proteomes; UP000007060; Unassembled WGS sequence.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0050334; F:thiaminase activity; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR CDD; cd19367; TenA_C_ScTHI20-like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 1.20.910.10; Heme oxygenase-like; 1.
DR InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR004305; Thiaminase-2/PQQC.
DR InterPro; IPR027574; Thiaminase_II.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR NCBIfam; TIGR04306; salvage_TenA; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF03070; TENA_THI-4; 1.
DR SUPFAM; SSF48613; Heme oxygenase-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
FT DOMAIN 33..283
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
FT DOMAIN 340..549
FT /note="Thiaminase-2/PQQC"
FT /evidence="ECO:0000259|Pfam:PF03070"
SQ SEQUENCE 551 AA; 61417 MW; 0F41EE6DF778514D CRC64;
MTYSTVNINR PPPYLALASN EKLPTVLSIA GTDPSGGAGI EADVKTITAH RCYAMTCITA
LNAQTPVKVY SINNTPKEVV SQILDANLQD MKCDVIKTGM LTTAAIEVLH EKLLQLGENR
PKLVVDPVLV ATSGSSLAGK DIASLITEKI APFADILTPN IPECFKLLGE DREITKLRDI
FEVAKDLAKI TKCSNILVKG GHIPWNDEEG KYITDVLYLG AEQRFITFKG NFVNTTHTHG
TGCTLASAIA SNLARGYSLP QSVYGGIEYV QNAVAIGCDV TKETVKDNGP INHVYAIEIP
LEKMLSDECF TASDAVHKKP VKSSLNKIPG GSFYKYLINH PKVKPHWDSY VNHDFVRKVA
DGSLEPKKFQ FFIEQDYLYL VNYARISCIA GSKSPCLEDL EKELVIVECV RNGLCQHERR
LREEFGIKDP DYLQKIQRGP ALRAYCRYFN DVSRRGNWQE LVIALNPCLM GYVHALTKIK
DEVTAAEGSV YREWCETYSS SWCHEAMLEG EKLLNHILET YPPEKLDTLV TIYAEVCELE
ANFWTAALEY E
//
