ID A70A_DROSE Reviewed; 55 AA.
AC O18417; B4HGQ9;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Accessory gland-specific peptide 70A;
DE AltName: Full=Paragonial peptide B;
DE AltName: Full=Sex peptide;
DE Short=SP;
DE Flags: Precursor;
GN Name=Acp70A; Synonyms=PAPB; ORFNames=GM25408;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9286679; DOI=10.1093/genetics/147.1.189;
RA Cirera S., Aguade M.N.;
RT "Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila
RT melanogaster.";
RL Genetics 147:189-197(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Represses female sexual receptivity and stimulates
CC oviposition.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Main cells of the accessory glands of males
CC (paragonial gland).
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DR EMBL; X99414; CAA67791.1; -; Genomic_DNA.
DR EMBL; CH480815; EDW41367.1; -; Genomic_DNA.
DR RefSeq; XP_002030381.1; XM_002030345.1.
DR AlphaFoldDB; O18417; -.
DR SMR; O18417; -.
DR STRING; 7238.O18417; -.
DR EnsemblMetazoa; FBtr0208393; FBpp0206885; FBgn0012779.
DR GeneID; 6605559; -.
DR KEGG; dse:6605559; -.
DR HOGENOM; CLU_3034552_0_0_1; -.
DR OMA; PNPRDKW; -.
DR OrthoDB; 3538781at2759; -.
DR PhylomeDB; O18417; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0046008; P:regulation of female receptivity, post-mating; IEA:InterPro.
DR InterPro; IPR012608; Sex_peptide.
DR Pfam; PF08138; Sex_peptide; 1.
PE 2: Evidence at transcript level;
KW Behavior; Disulfide bond; Hydroxylation; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT CHAIN 20..55
FT /note="Accessory gland-specific peptide 70A"
FT /id="PRO_0000020588"
FT MOD_RES 28
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 32
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 34
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250"
FT MOD_RES 38
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250"
FT DISULFID 43..55
FT /evidence="ECO:0000250"
SQ SEQUENCE 55 AA; 6438 MW; E87AD0919657A83D CRC64;
MKTLSVFLVL VCLLGLVQSW EWPWNRQPTR YPIPSPNPRD KWCRLNLGPA WGGRC
//
