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Database: UniProt
Entry: A7APA6_BABBO
LinkDB: A7APA6_BABBO
Original site: A7APA6_BABBO 
ID   A7APA6_BABBO            Unreviewed;       927 AA.
AC   A7APA6;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   07-JUN-2017, entry version 33.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=BBOV_III008300 {ECO:0000313|EMBL:EDO08390.1};
OS   Babesia bovis.
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO08390.1, ECO:0000313|Proteomes:UP000002173};
RN   [1] {ECO:0000313|EMBL:EDO08390.1, ECO:0000313|Proteomes:UP000002173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T2Bo {ECO:0000313|EMBL:EDO08390.1,
RC   ECO:0000313|Proteomes:UP000002173};
RX   PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA   Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA   Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA   Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H.,
RA   Koo H., Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q.,
RA   Smith R.K. Jr., Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr.,
RA   McElwain T.F., Nene V.M.;
RT   "Genome sequence of Babesia bovis and comparative analysis of
RT   apicomplexan hemoprotozoa.";
RL   PLoS Pathog. 3:1401-1413(2007).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EDO08390.1}.
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DR   EMBL; AAXT01000001; EDO08390.1; -; Genomic_DNA.
DR   RefSeq; XP_001611958.1; XM_001611908.1.
DR   EnsemblProtists; EDO08390; EDO08390; BBOV_III008300.
DR   GeneID; 5480210; -.
DR   KEGG; bbo:BBOV_III008300; -.
DR   EuPathDB; PiroplasmaDB:BBOV_III008300; -.
DR   InParanoid; A7APA6; -.
DR   KO; K02154; -.
DR   OMA; FILRANH; -.
DR   Proteomes; UP000002173; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002173};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002173};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    488       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    509    526       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    596    617       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    629    652       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    693    712       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    857    882       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   927 AA;  106577 MW;  43F806EB152E6981 CRC64;
     MGIFRSVTMS HGTLVIPQER ARDCIDLLCR NTNIQFVDMN ERRLDRPYKK YIQRILNMER
     MIRVLTEEVT SLPGTMIVKD RIDDFLRYDK VYRLDQVEES LVKLYEQFEK FKQNDLMLKT
     ELEEVMNEYS VMLVALKQLN ASKKQGFLPT DTRVQKSSGM DESAESNAQL LSESDENGEV
     LDTEMVNISP SPESDSSGST LAFSNIAGVI SAEDKDAFSR AIFRAMRGNV YTFFQDSQVI
     KEAILSRGLI TEEEASIRGN EEKIVFVIYC QSASGSSTFQ KLQKLCNGFQ AKTFAWSKSH
     SHINQRLQEL EEIIRDRQKA LNAFKRYFRE EIACLLECPR PDGNSVIEEW SLFCRKEKYI
     YYILNHFEGS DITLRADCWF PEEEEETIRT CLQAEKSEGR VSALLLIDHQ FKERRYFDDP
     ATMPPTYNKN DVFTSAFQGV VDTYGVPRYK EMNPTPFTIV TFPFLFGIMF GDIGHGMCVI
     LAGLFLIIRY PQLRKKYNDE MALMILNGRY MILLMGIFAT YTGFIYNDFL SLPNNFFGSC
     WVRERAALAH GAAAAGEVTE TLVKSTESFP VSFGLDVAWI HAVNEQPMLH SFKMKLSIIV
     GFLQMMMGIL LKGMNAIYFR QPLDFFFEFI PQLVLMCCFV GYITFLIFYK WLTPVTADYP
     KPSIIITLID MCLFKELAEH DVMYPGQRHV QKVLVSMMML CIPLMLLPKP LYMWYQQRRR
     IVIGDDHPKD HEMVYRGYDD VENNVSEIAN AEIIDREENA VETSPFKRVA TDSTRYEGEF
     AVTIHNDGTI SEDHSGGHSM TDIFIHQLIE TIEFSLGIIS NTASYLRLWA LSLSHQQLSA
     VFFNQTVLRT LSGESGVVGT TISLFFTSTL FAVITAAVML GMDTLECYLH AMRLQWVEFQ
     NKFYKADGKP FKPFNVKVLL ENPETEQ
//
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