ID A7AS70_BABBO Unreviewed; 532 AA.
AC A7AS70;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Aspartyl protease, putative {ECO:0000313|EMBL:EDO07389.1};
GN ORFNames=BBOV_IV010360 {ECO:0000313|EMBL:EDO07389.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO07389.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO07389.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO07389.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO07389.1}.
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DR EMBL; AAXT01000002; EDO07389.1; -; Genomic_DNA.
DR RefSeq; XP_001610957.1; XM_001610907.1.
DR AlphaFoldDB; A7AS70; -.
DR STRING; 5865.A7AS70; -.
DR EnsemblProtists; EDO07389; EDO07389; BBOV_IV010360.
DR VEuPathDB; PiroplasmaDB:BBOV_IV010360; -.
DR eggNOG; KOG1339; Eukaryota.
DR InParanoid; A7AS70; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000313|EMBL:EDO07389.1};
KW Protease {ECO:0000313|EMBL:EDO07389.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..532
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002706882"
FT DOMAIN 185..511
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 203
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 403
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 216..221
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 532 AA; 58573 MW; 50A2A496DDD5812B CRC64;
MVIATLIAAI VWQACISKIC YPAWVLSVVD AAPIGKTPSG SLKDCPSHKI DVYKGPKPKI
VLPMIPMQNN NTPGAFMQIG NTISLPPKSS VVKQHKDNIS KTKSGKVATV FPGRGPNGSM
GVDMETKRRH EERIRKQSLE QLAAMDNNTS EKDEIPVTVT RQETAFPRVP ANACLDFASL
RHTTFVVEAY IGKPGQKFLP ILDTGSTNVW AIHPECTSAG CMEAIKYDPA RSKTFKPLEA
ADSIVRARFV SGVVLGTLGY DDFTIGGFTV KGQLFAMMRD IPDKSTNDIL TVSNGQNVDI
FTQETPFNGM IGLGFKDLMV MNSEPLYQRY MKVVGAEPIF SFYYSRNGVG SAFLVGGADE
RLHKGPMQMM PVVPGYYWQV ELEEVFVGKR KVCCDKQSYA VFDTGTAFNS MPHAAINTLL
EEYPFYECNA ENMNRVYAAL PTIKYTFSNG VQAKLTPEQY TYESEGVCRP AFMQINVDVA
GGEGYLLGSM AFMPHYYTVY YGGESPMIGI APSNHENAPK VVAEYTSKHK KA
//