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Database: UniProt
Entry: A7AU66_BABBO
LinkDB: A7AU66_BABBO
Original site: A7AU66_BABBO 
ID   A7AU66_BABBO            Unreviewed;       208 AA.
AC   A7AU66;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=CDP-diacylglycerol--inositol 3-phosphatidyltransferase {ECO:0000256|ARBA:ARBA00013212, ECO:0000256|PIRNR:PIRNR000848};
DE            EC=2.7.8.11 {ECO:0000256|ARBA:ARBA00013212, ECO:0000256|PIRNR:PIRNR000848};
GN   ORFNames=BBOV_II005250 {ECO:0000313|EMBL:EDO06477.1};
OS   Babesia bovis.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Babesiidae; Babesia.
OX   NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO06477.1, ECO:0000313|Proteomes:UP000002173};
RN   [1] {ECO:0000313|EMBL:EDO06477.1, ECO:0000313|Proteomes:UP000002173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T2Bo {ECO:0000313|EMBL:EDO06477.1};
RX   PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA   Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA   Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA   Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA   Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA   Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA   Nene V.M.;
RT   "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT   hemoprotozoa.";
RL   PLoS Pathog. 3:1401-1413(2007).
RN   [2] {ECO:0000313|Proteomes:UP000002173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA   Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA   Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT   "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT   invertebrate hosts.";
RL   Data Brief 33:106533-106533(2020).
RN   [3] {ECO:0000313|Proteomes:UP000002173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=33069745;
RA   Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA   Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT   "Comparative analysis of gene expression between Babesia bovis blood stages
RT   and kinetes allowed by improved genome annotation.";
RL   Int. J. Parasitol. 51:123-136(2021).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-
CC         glycero-3-phospho-(1D-myo-inositol) + CMP + H(+);
CC         Xref=Rhea:RHEA:11580, ChEBI:CHEBI:15378, ChEBI:CHEBI:17268,
CC         ChEBI:CHEBI:57880, ChEBI:CHEBI:58332, ChEBI:CHEBI:60377; EC=2.7.8.11;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000848};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000256|PIRNR:PIRNR000848}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDO06477.1}.
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DR   EMBL; AAXT01000003; EDO06477.1; -; Genomic_DNA.
DR   RefSeq; XP_001610045.1; XM_001609995.1.
DR   AlphaFoldDB; A7AU66; -.
DR   STRING; 5865.A7AU66; -.
DR   EnsemblProtists; EDO06477; EDO06477; BBOV_II005250.
DR   GeneID; 5478277; -.
DR   KEGG; bbo:BBOV_II005250; -.
DR   VEuPathDB; PiroplasmaDB:BBOV_II005250; -.
DR   eggNOG; KOG3240; Eukaryota.
DR   InParanoid; A7AU66; -.
DR   OMA; FWFQLSM; -.
DR   Proteomes; UP000002173; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003881; F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   InterPro; IPR014387; CDP_diag_ino_3_P_euk.
DR   PANTHER; PTHR15362:SF4; CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE; 1.
DR   PANTHER; PTHR15362; PHOSPHATIDYLINOSITOL SYNTHASE; 1.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   PIRSF; PIRSF000848; CDP_diag_ino_3_P; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|PIRNR:PIRNR000848};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|PIRNR:PIRNR000848};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000848};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phospholipid biosynthesis {ECO:0000256|PIRNR:PIRNR000848};
KW   Phospholipid metabolism {ECO:0000256|PIRNR:PIRNR000848};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002173};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000848};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        93..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        138..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   208 AA;  24585 MW;  08FE3FBB2C56532D CRC64;
     MARNPRYLTK ANGVTMIRTI LIMIGMFFAR RNPFVFVSLY TASHLLDMLD GYVSRYYNES
     TLVGAAFDQL LDRMSSTYLC FLNARQYPRC LEVFYLIMLI DICGHWIHNY ACALYSNTNH
     KDVKDANIFL RVYYHKRWLM FMSIVMYETF FCTLYIRSMY HPGDYIYGLV NYFLLVSSPL
     CGYKILTNVL QGIYGCRRIM HYDISTSK
//
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