ID A7AW26_BABBO Unreviewed; 833 AA.
AC A7AW26;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Chaperone clpB, putative {ECO:0000313|EMBL:EDO05254.1};
GN ORFNames=BBOV_I001700 {ECO:0000313|EMBL:EDO05254.1};
OS Babesia bovis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=5865 {ECO:0000313|EMBL:EDO05254.1, ECO:0000313|Proteomes:UP000002173};
RN [1] {ECO:0000313|EMBL:EDO05254.1, ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T2Bo {ECO:0000313|EMBL:EDO05254.1};
RX PubMed=17953480; DOI=10.1371/journal.ppat.0030148;
RA Brayton K.A., Lau A.O.T., Herndon D.R., Hannick L., Kappmeyer L.S.,
RA Berens S.J., Bidwell S.L., Brown W.C., Crabtree J., Fadrosh D.,
RA Feldblum T., Forberger H.A., Haas B.J., Howell J.M., Khouri H., Koo H.,
RA Mann D.J., Norimine J., Paulsen I.T., Radune D., Ren Q., Smith R.K. Jr.,
RA Suarez C.E., White O., Wortman J.R., Knowles D.P. Jr., McElwain T.F.,
RA Nene V.M.;
RT "Genome sequence of Babesia bovis and comparative analysis of apicomplexan
RT hemoprotozoa.";
RL PLoS Pathog. 3:1401-1413(2007).
RN [2] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33294524; DOI=10.1016/j.dib.2020.106533;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Transcriptome dataset of Babesia bovis life stages within vertebrate and
RT invertebrate hosts.";
RL Data Brief 33:106533-106533(2020).
RN [3] {ECO:0000313|Proteomes:UP000002173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33069745;
RA Ueti M.W., Johnson W.C., Kappmeyer L.S., Herndon D.R., Mousel M.R.,
RA Reif K.E., Taus N.S., Ifeonu O.O., Silva J.C., Suarez C.E., Brayton K.A.;
RT "Comparative analysis of gene expression between Babesia bovis blood stages
RT and kinetes allowed by improved genome annotation.";
RL Int. J. Parasitol. 51:123-136(2021).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO05254.1}.
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DR EMBL; AAXT01000005; EDO05254.1; -; Genomic_DNA.
DR RefSeq; XP_001608822.1; XM_001608772.1.
DR AlphaFoldDB; A7AW26; -.
DR STRING; 5865.A7AW26; -.
DR EnsemblProtists; EDO05254; EDO05254; BBOV_I001700.
DR GeneID; 5477038; -.
DR KEGG; bbo:BBOV_I001700; -.
DR VEuPathDB; PiroplasmaDB:BBOV_I001700; -.
DR eggNOG; KOG1051; Eukaryota.
DR InParanoid; A7AW26; -.
DR Proteomes; UP000002173; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002173}.
FT DOMAIN 199..335
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 596..738
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 445..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 92887 MW; 5F745840C884BBF2 CRC64;
MYNIKNLVFY HLNTYNVRRF SVWRQLSPVC DLSTEVSAVL NHASELAKRS GSGSIESEFI
VKSLLDSCSS YRKWLRTIRL SPGPIATELD DFIKRRRYTN GEERVGRSSQ SAILYAQSLA
LSRSKPVGIL ELSEALLKYD DFLRGIHQRS DAGKPKVDQN AVEECLYNLT EAAKNGSGNV
FVGRENELER LKGSLNRMRK NNVLLIGEPG VGKTALVERL AVDMLLEDPN ITVYSLDLCR
LYSGQGTRGE LEAKLKSIFD TVKNGKSILF IDEIHHLIQN QENGVNVTNL LKPIMTSTLV
KIIGSTTAKE YHQYFRRDRA FERRFEILRL HENSADETLA ILHGSRPSLE DYHGVKITDD
ALVASVELST RFIPNRYLPD KAIDLLDEAA MLSKRKRSCS NDLFELLRHK TGIISALLRG
KSGNDQLNRV LSEIESMESR YKSLHGKLRD VQQQQQNHEK NGNLTKASEL KNHKIPEIIR
LIVQLQSDIK MVINKTIEDS KDMLPVDMLN DGNTGVSPAS DPDVFSGVYV DRIDIASALS
QSTGIPVSVV LRSQMGHYEQ AVQQLSNIVL GQNEAVYKTL LHIYMYSSSI ASGRKIGAAL
YYVGPPGVGK RLLLNHVSRM FGMALKYICG SNLVSSNATN ILVGSPPGYI GHREGGMLCE
WIKDHPYGIV AFEDAHLLHV NVVNLLIGAI DNGFLVDNQG DQCNLRQCFF VFVSNDHEQL
SPLIKQNADD VISFEPLSKE SVERIICKEL ASIDVVKLRA SKAALEHLYH LAIGTKSIPN
LIYRTLGSSI ANLVVSGRVP IGASGELIMK SEVNLHCNHS IHICDDMVLV RDV
//
