ID   A7EQE3_SCLS1            Unreviewed;       851 AA.
AC   A7EQE3;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=Anaphase-promoting complex subunit 2 {ECO:0000256|ARBA:ARBA00016068};
GN   ORFNames=SS1G_07545 {ECO:0000313|EMBL:EDN91685.1};
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN91685.1, ECO:0000313|Proteomes:UP000001312};
RN   [1] {ECO:0000313|Proteomes:UP000001312}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX   PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476630; EDN91685.1; -; Genomic_DNA.
DR   RefSeq; XP_001590921.1; XM_001590871.1.
DR   AlphaFoldDB; A7EQE3; -.
DR   STRING; 665079.A7EQE3; -.
DR   GeneID; 5487230; -.
DR   KEGG; ssl:SS1G_07545; -.
DR   InParanoid; A7EQE3; -.
DR   OMA; VTTWQAT; -.
DR   OrthoDB; 2786196at2759; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR044554; APC2-like.
DR   InterPro; IPR014786; APC2_C.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45957; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR45957:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 2; 1.
DR   Pfam; PF08672; ANAPC2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   SMART; SM01013; APC2; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          513..725
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          757..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  95024 MW;  6CAD56185AE36A00 CRC64;
     MATLTARRKR VFDSVFKKPE ISEPTPVASP TGSFTTPSQP FEGPENFNNE PKRPSSSNTT
     SSQQLGGHIG DQSVDQVRDQ IQWDRSWHTV TYRLQLSDVP PDPSSIETLE SLSIPPDPSF
     DGALKDVLDS ARRLPFALHT EDLLVWHTQQ VRRHLLHRIL PMLRGFTNAE GAESLVFGSL
     ITALKTVLEN YVSSILGLRG GEGSGIAPIS TRTDEVCNEM LNLVESLYKV GLARENFQVI
     FAEIMNRSMT EYVNRGCRGL WSSNQVNMTP EDGDRRNSVL PRTAHHVSPS NCVTDLCGWI
     EDRYSKLAVL VFKVIDNVEV AWSDMEKWKE MSIGRLAALR TDELFDIVVN WPNSNGALHD
     LRTTITTPQR RLHLTEVFAA TLKERLLHPG ASTLLILQTY ISMIWSFHSL DHSKVLLDRV
     AYPLQVYLCS REDTVRIIIT GLLSDTVDAQ GNPVEPGGDR LIELAQLLND NSEQSGRNID
     DEELDWHDME WVPDPVDAGP GYKRSKNADI IGTLIGFFGS QEVFIKEFQS IISENLLKND
     GAFEKEIKVL ELLKSRFGES PLQSCEVMLK DILDSVRLDL AIRKTQELSL AEREATPPPP
     SQPILHTKIL SRLFWPPLQE SAFTLPPQIT NLQSHYSTAF SSLKPARKLT WLPALGHTTV
     ELELADRTVV EECTTWQATV ISCFHSETSS IDADEEVGLS KSIEELSSEL QMESTLILSA
     LKFWASKLVL HESPPKSQIY SVLETLNASE RARSDALASA TANADNNDDE GEGGKGEKGI
     TGEHAKVYWQ FVQSMLTNSS SRMGAPQIAM MLKMLIAEGF PYSNEELLEW LGGKVEEGVL
     ECVGGRYKLR K
//