ID A7F001_SCLS1 Unreviewed; 1184 AA.
AC A7F001;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Ras guanine-nucleotide exchange protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SS1G_10918 {ECO:0000313|EMBL:EDN95043.1};
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079 {ECO:0000313|EMBL:EDN95043.1, ECO:0000313|Proteomes:UP000001312};
RN [1] {ECO:0000313|Proteomes:UP000001312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1 {ECO:0000313|Proteomes:UP000001312};
RX PubMed=21876677; DOI=.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Guldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
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DR EMBL; CH476636; EDN95043.1; -; Genomic_DNA.
DR RefSeq; XP_001588471.1; XM_001588421.1.
DR AlphaFoldDB; A7F001; -.
DR STRING; 665079.A7F001; -.
DR GeneID; 5484219; -.
DR KEGG; ssl:SS1G_10918; -.
DR InParanoid; A7F001; -.
DR OMA; EEVWERD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001312};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 81..147
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 719..839
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 899..1142
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..572
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 129877 MW; 02A89E5DA6609C39 CRC64;
MVNSNESEHS KRTSAQVAPL TIQKGRSRGN SNASSKKHKR NTSSKGGSQT TSTGNQSQIT
PPATPNASQE NLNQMEPPPP VFHSFLRAFY PFHPTYAISD STVTLPLNEG DVVLVHSIHT
NGWADGTLLV SGARGWLPTN YCEAYDPDSM RNLLKALLNF WDLLRSGLTS DSEIFGNQQF
MRGIIAGEKS NCLTRESPIV QSNDNLRKNR KALLSDLSAL VKTAKQLQDF ATSPPAKTDA
ESVNDIIDEM ILKAFKIVVR GIKFLDNLEE DAKLRQPLHK VMATVAEESY VPPTPPADST
SFSGAPHTDP ADDTASHRSS IRSSASGASS SLPSEEQNKQ QSHKRVSTAC PAVTSRPLSI
SSTQAKRASV SHRVSFIASV PTEQRQNLVS ERLNCGHDTF LSYLGSFIGR LHLQSQSSLD
LLSSVRQSVT AGQGLLIVVE AVCAHDSQSA DLLNNARNAM YDKISKLALA ARDIVSSSGV
DEDDVVMAQQ NGGLLMAATG CVKAAGEVVA KTKFVIERIG DFEFEQVEGL GINVASIDVV
PKHTIQEDEV IEETPEQHSS RPPPPPLVIP NVYEKPLPEV PLDSPPATEV KRMSNRLSNT
SILPPLPKMG APLMSQEDYS PSDRASTSDG EFQSYRSASI AVSSTGTSSS YMRDSEISMI
SQTSTRATTP DLTSHKPRNQ PSISSICMSE SQSTFADDPY DLESKMLEKT FAHELLHNKE
GQITGGSIAA LVERLTTHDS TPDSMFVSTF YLTFRLFASP IELANALVDR FEYVGETPHI
AGPVRLRVYN VFKGWLESHW RKVSDYAALS IIETFANDKL KAALPAAGKR LYDLAQKVSS
IDGSLVPRLV SSIGKTSTSF GQYVPADVPV PPVVVTKSQA AVLKNWKMGG SNPSIIEFDP
LELARQLTIK EMNIFCSIMP DELLGATWTK ARKGGSSAVN VKAMSTLSTD LSNLVADTIL
QYDDVKKRAV IIKHWIKIAH ECFRLNNYDS LMAIICSLNS STIVRLKKTW DLVPQKRKDM
LKALQTVVEP EKNYAVLRRR LHDHVPPCLP FVGTYLTDLT FVDAGNPATK QLADGTSVIN
FDKHTRTAKI IGELQRFQIP YRLAEVPELQ EWLQAQIVRV KSASDHENVQ QYYRKSLLLE
PRDVLVTKPS PVDSAVSFTS SQGKDKFDIF GWTHSSKDKT QTPI
//
