ID A7GWP0_CAMC5 Unreviewed; 773 AA.
AC A7GWP0;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:EAT99633.1};
GN ORFNames=CCV52592_1645 {ECO:0000313|EMBL:EAT99633.1};
OS Campylobacter curvus (strain 525.92).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=360105 {ECO:0000313|EMBL:EAT99633.1, ECO:0000313|Proteomes:UP000006380};
RN [1] {ECO:0000313|Proteomes:UP000006380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=525.92 {ECO:0000313|Proteomes:UP000006380};
RA Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA Mandrell R.E., Lastovica A.J., Nelson K.E.;
RT "Genome sequence of Campylobacter curvus 525.92 isolated from human
RT feces.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000767; EAT99633.1; -; Genomic_DNA.
DR RefSeq; WP_011991849.1; NC_009715.2.
DR AlphaFoldDB; A7GWP0; -.
DR STRING; 360105.CCV52592_1645; -.
DR KEGG; ccv:CCV52592_1645; -.
DR HOGENOM; CLU_000445_129_3_7; -.
DR OrthoDB; 5372181at2; -.
DR Proteomes; UP000006380; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006380};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 379..511
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 518..773
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 314..349
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 773 AA; 87474 MW; BB72E5DBA8D6CB6E CRC64;
MLKKISNGHQ AAFLYIGVLF CAYAVVLNFG KQLYCDVTSI LLNVSIALIM LYRLKMTKNL
NSYWVWIVLG VIGWVVADVL WAGYNMSHEN SSLEALFFIQ VIYFIPFILF LAASVAIFIR
SNKSGLWTQA LIDAGVILMI YASFFWFVVF DRDLSFVLST DFAFHLVYIF VDIVMFCIVF
IVYFSVHTMK RRLSFFLCLA ALGLFCVYDM YYSVMTANGK DLTNTNYELV LELVFVLFFL
AALHLKRGEV RLKFRKNRED FHRILINKLL LLFVVLAFAI VISGKIDLSW GIFIMILMLA
YAVLTHSISS VRNNQLLIAK EQNVKQKLDK MIEERVQELS QTNKRLKQLS EYDFLTGALN
RPFFLLKLEE MIKTKALGEN IDIYSIDINH FKSVNDSYGH YVGDEVLARV VKNIKSVLPK
NSLLARFGGD DFMVVAKQKG DGYFREFLTR LHAAISQPIL IESYKISLSA KIGISTTATS
EILAEDLIAQ AGVALNSAKK NTLCEHVFYD DIKDMIQEQN YIEILLNSIN FDREFRLNFQ
PQYLIEGKKL IGAEALIRWN SPIKGFVSPA LFIPIAEQSS IINSIGKWVA KEAIKQMSAW
NQKYATALKI GINVSPKQVD NVNFASDILG FIKEFNIDPR CVDIEITEAS LVNAEEIMQS
VLGVFSQNGI SISIDDFGTG FSSMSYIKKY AINKLKIAKE LVDNIASNEI DKDVATSIIS
LAKNINVKTI AEGVEDATQL EILKSCGCDE VQGYFWGKPM SAAEFEELIK SSI
//
