ID A7GZ92_CAMC5 Unreviewed; 689 AA.
AC A7GZ92;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 24-JAN-2024, entry version 89.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=CCV52592_0699 {ECO:0000313|EMBL:EAU00431.1};
OS Campylobacter curvus (strain 525.92).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=360105 {ECO:0000313|EMBL:EAU00431.1, ECO:0000313|Proteomes:UP000006380};
RN [1] {ECO:0000313|Proteomes:UP000006380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=525.92 {ECO:0000313|Proteomes:UP000006380};
RA Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA Mandrell R.E., Lastovica A.J., Nelson K.E.;
RT "Genome sequence of Campylobacter curvus 525.92 isolated from human
RT feces.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP000767; EAU00431.1; -; Genomic_DNA.
DR RefSeq; WP_011992465.1; NC_009715.2.
DR AlphaFoldDB; A7GZ92; -.
DR STRING; 360105.CCV52592_0699; -.
DR KEGG; ccv:CCV52592_0699; -.
DR HOGENOM; CLU_004585_5_2_7; -.
DR OMA; YQDTNRT; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000006380; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:EAU00431.1};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000006380}.
FT DOMAIN 6..288
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 289..557
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 689 AA; 78479 MW; E14A6D478392126F CRC64;
MENLLDNLND AQREAARHID GPMLILAGAG SGKTKTITTR LAYLIGEVGI DPANTLTLTF
TNKAANEMRT RALAMLNQSG KACTPLLCTF HKFGLLFLKF HIDRLGRKNN FIIIDTDDKK
RIIKSFESPI STAILSSEIS NYKNSLLSVE EVYKNANFLT NEKGKENFYQ KAAAIYDKYE
EYLRANNLVD FDDLLVLTYK ILDENEDLAR EISNRYRYIM VDEYQDTNDL QYKLLRKLCL
THENICVVGD DDQSIYGWRG AKIENILNFK DQFKNTKIIR LEQNYRSTTP ILKAANELID
HNRNRLGKKL LSVKGEGEGV NLLESLDESV EAGKIAKSIK ELLEKGAQAK DIAILYRINA
LSRSLEDGLT KERIPYKMVG GVKFYERAEV KDVISYLRLI INQNDDFSLK RIINRPKRGL
GKVSLDKLEK MAYEGKTSMF DAILNIDDKD EAFSKKIKTA LVEFTQILKE LQETNSLYEL
IDKMEAKFGI KKYYESLPDG NERAANIDEF YAMLKDQIKQ NPSFELEEFL NELALVSEQD
NISSEAISIM SVHASKGLEF EYLFVIGLEE GFFPLIGDGS DIEEERRLAY VAITRAKKLL
TLSFANSRFY KGQRTRLNKS RFLSESGTTQ GSLVIEESNE FKKGDLVKHK IFGIGRVTAV
SKVKKEFKLT INFAGNVREI MSSFVEKAV
//