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Database: UniProt
Entry: A7I439
LinkDB: A7I439
Original site: A7I439 
ID   ILVD_CAMHC              Reviewed;         553 AA.
AC   A7I439;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   26-NOV-2014, entry version 47.
DE   RecName: Full=Dihydroxy-acid dehydratase {ECO:0000255|HAMAP-Rule:MF_00012};
DE            Short=DAD {ECO:0000255|HAMAP-Rule:MF_00012};
DE            EC=4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012};
GN   Name=ilvD {ECO:0000255|HAMAP-Rule:MF_00012};
GN   OrderedLocusNames=CHAB381_1769;
OS   Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 /
OS   CH001A).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=360107;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A;
RA   Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA   Mandrell R.E., Nelson K.E.;
RT   "Complete genome sequence of Campylobacter hominis ATCC BAA-381, a
RT   commensal isolated from the human gastrointestinal tract.";
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-
CC       oxobutanoate + H(2)O. {ECO:0000255|HAMAP-Rule:MF_00012}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00012};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000255|HAMAP-Rule:MF_00012};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 3/4. {ECO:0000255|HAMAP-
CC       Rule:MF_00012}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 3/4. {ECO:0000255|HAMAP-Rule:MF_00012}.
CC   -!- SIMILARITY: Belongs to the IlvD/Edd family. {ECO:0000255|HAMAP-
CC       Rule:MF_00012}.
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DR   EMBL; CP000776; ABS51486.1; -; Genomic_DNA.
DR   RefSeq; WP_012109587.1; NC_009714.1.
DR   RefSeq; YP_001407280.1; NC_009714.1.
DR   STRING; 360107.CHAB381_1769; -.
DR   EnsemblBacteria; ABS51486; ABS51486; CHAB381_1769.
DR   GeneID; 5409052; -.
DR   KEGG; cha:CHAB381_1769; -.
DR   PATRIC; 20041638; VBICamHom81367_1685.
DR   eggNOG; COG0129; -.
DR   HOGENOM; HOG000173155; -.
DR   KO; K01687; -.
DR   OMA; CRWDSVD; -.
DR   OrthoDB; EOG6MSS24; -.
DR   BioCyc; CHOM360107:GHCX-1774-MONOMER; -.
DR   UniPathway; UPA00047; UER00057.
DR   UniPathway; UPA00049; UER00061.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00012; IlvD; 1.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR004404; DihydroxyA_deHydtase.
DR   InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR   InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR   PANTHER; PTHR21000; PTHR21000; 1.
DR   Pfam; PF00920; ILVD_EDD; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR00110; ilvD; 1.
DR   PROSITE; PS00886; ILVD_EDD_1; 1.
DR   PROSITE; PS00887; ILVD_EDD_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Amino-acid biosynthesis;
KW   Branched-chain amino acid biosynthesis; Complete proteome; Iron;
KW   Iron-sulfur; Lyase; Metal-binding; Reference proteome.
FT   CHAIN         1    553       Dihydroxy-acid dehydratase.
FT                                /FTId=PRO_1000000971.
FT   METAL       119    119       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_00012}.
FT   METAL       192    192       Iron-sulfur (4Fe-4S). {ECO:0000255|HAMAP-
FT                                Rule:MF_00012}.
SQ   SEQUENCE   553 AA;  59425 MW;  26D2881C75D4B2DB CRC64;
     MRSDVIKKGY IRAPHRSLLR ATGLKDDDFK KPFIGVCNSF AEIIPGHFFL NKFAKIIKDE
     IRKNGCVPFE FNCIGVDDGI AMGHDGMLYS LPSREIIANS VETMMNAHKL DALICIPNCD
     KIVPGMIMGA LRVNVPTIFI SGGPMAAGRG KNGEALDLNS TFEAVGAYEV KKINKKELHD
     IECAACPGAG SCSGMFTANS MNTLCEAMGI ALKGNGTILA MTKNRKKLAK KAARRICEIA
     LDDKFKIRNI INKKAVENAM VVDMAMGGSS NTILHMLAIS REAGCALDIK ELNEISKKTP
     HIAKIAPSKP EIHMQDVHNA GGINAIMNEV KDLLHLDNLT VTGETLGERI KGAKIKDEDV
     IHKVENAYSK VGGLAILFGN LAEQGCVIKA AGIIGSRKFS GKAICFNSQD EAIEGISGGK
     VKKGDVVVIR YEGPKGGPGM QEMLSPTSLI VGRGLGADVA LITDGRFSGA TRGLCIGHVS
     PEAAEGGMIG LLKDGDIIDI DVDNFSINVR LSEDEIAERK KEFKYGGKKV QSRWLRQYQK
     LVTNASNGAI LEA
//
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