ID A7IIK9_XANP2 Unreviewed; 375 AA.
AC A7IIK9;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Alcohol dehydrogenase zinc-binding domain protein {ECO:0000313|EMBL:ABS67852.1};
GN OrderedLocusNames=Xaut_2610 {ECO:0000313|EMBL:ABS67852.1};
OS Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Xanthobacter.
OX NCBI_TaxID=78245 {ECO:0000313|EMBL:ABS67852.1, ECO:0000313|Proteomes:UP000002417};
RN [1] {ECO:0000313|EMBL:ABS67852.1, ECO:0000313|Proteomes:UP000002417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1158 / Py2 {ECO:0000313|Proteomes:UP000002417};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.,
RA Detter J.C., Han C., Tapia R., Brainard J., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Kim E., Ensigns S.A., Richardson P.;
RT "Complete sequence of chromosome of Xanthobacter autotrophicus Py2.";
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP000781; ABS67852.1; -; Genomic_DNA.
DR AlphaFoldDB; A7IIK9; -.
DR STRING; 78245.Xaut_2610; -.
DR KEGG; xau:Xaut_2610; -.
DR eggNOG; COG1062; Bacteria.
DR HOGENOM; CLU_026673_14_1_5; -.
DR OrthoDB; 9770544at2; -.
DR PhylomeDB; A7IIK9; -.
DR Proteomes; UP000002417; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08281; liver_ADH_like1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002417};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 18..374
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 375 AA; 38594 MW; E4B4C98A7E6AC472 CRC64;
MRIRAAVLRA SPVSKPYGQT RPLSIETVEL APPQAGEVLI KIAAAGLCHS DLSVINGDRP
RQLPMVLGHE ASGVVVEPGP GVTDLAPGDH VVMSFVPTCG TCPSCLDGRA QMCGPGQAAN
GAGTLLGGGR RLTCDDGTDA YHLCGISGFG EYAVISRRSI IKIDPEMSLV DAALFGCAVM
TGVGAIVNTC GVRPGQSVAV VGLGGVGLSA VMGAVAAGAE QIVALDLSPA KLDIARSLGA
TDTFLANDPD VVDAVKAATK GGVDHAVEMA GSAPAFELAY KITRRGGTTA TGGLANPNAR
VSLPPVHLVA EERTIKGSYM GSCVPPRDIP RFMALYQRGK LPVNRLLSST GPLDEINEGF
DRLDRGEVVR HVIVY
//
