ID A7KGQ7_9NEOB Unreviewed; 240 AA.
AC A7KGQ7;
DT 11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT 11-SEP-2007, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ABS86698.1};
OS Stumpffia psologlossa (Madagascar stump-toed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Microhyloidea; Microhylidae; Cophylinae;
OC Stumpffia.
OX NCBI_TaxID=289226 {ECO:0000313|EMBL:ABS86698.1};
RN [1] {ECO:0000313|EMBL:ABS86698.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17369057; DOI=10.1016/j.ympev.2007.02.008;
RA van der Meijden A., Vences M., Hoegg S., Boistel R., Channing A., Meyer A.;
RT "Nuclear gene phylogeny of narrow-mouthed toads (Family: Microhylidae) and
RT a discussion of competing hypotheses concerning their biogeographical
RT origins.";
RL Mol. Phylogenet. Evol. 44:1017-1030(2007).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; EF396033; ABS86698.1; -; Genomic_DNA.
DR AlphaFoldDB; A7KGQ7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 129..236
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 137..204
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 182..233
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 192..235
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABS86698.1"
FT NON_TER 240
FT /evidence="ECO:0000313|EMBL:ABS86698.1"
SQ SEQUENCE 240 AA; 26980 MW; 1FD2704D2436BD2B CRC64;
PTMVISYLSC MKAAPMKEAN IRGQSGLAYP GLRTHGTLDN IGGPIGGSRG GGLPSLTDTF
EHVIEELLEE EQTIRQSEEN KDSDMYTSRV MLSTQVPLEP PLLFLLEEYK NYLDAANMSM
RVRRHSDPAR RGELSVCDSI SEWVTAADKK TAVDMAGQTV TVLEKVPVPK GQLKQYFYET
KCNPMGYMKE GCRGIDKRYW NSQCRTTQSY VRALTMDSKK KVGWRFIRID TSCVCTLTIK
//
