ID A7MBB9_BOVIN Unreviewed; 168 AA.
AC A7MBB9;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=CDKN2C protein {ECO:0000313|EMBL:AAI51478.1};
DE SubName: Full=Cyclin dependent kinase inhibitor 2C {ECO:0000313|Ensembl:ENSBTAP00000014685.3};
GN Name=CDKN2C {ECO:0000313|EMBL:AAI51478.1,
GN ECO:0000313|Ensembl:ENSBTAP00000014685.3,
GN ECO:0000313|VGNC:VGNC:27146};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI51478.1};
RN [1] {ECO:0000313|EMBL:AAI51478.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI51478.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:AAI51478.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000014685.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000014685.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000014685.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000014685.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC151477; AAI51478.1; -; mRNA.
DR RefSeq; NP_001094524.1; NM_001101054.2.
DR RefSeq; XP_005204592.1; XM_005204535.3.
DR STRING; 9913.ENSBTAP00000014685; -.
DR PaxDb; 9913-ENSBTAP00000014685; -.
DR Ensembl; ENSBTAT00000014685.4; ENSBTAP00000014685.3; ENSBTAG00000011059.4.
DR GeneID; 505691; -.
DR KEGG; bta:505691; -.
DR CTD; 1031; -.
DR VEuPathDB; HostDB:ENSBTAG00000011059; -.
DR VGNC; VGNC:27146; CDKN2C.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160194; -.
DR HOGENOM; CLU_000134_37_0_1; -.
DR OMA; MAEPLGN; -.
DR OrthoDB; 2321802at2759; -.
DR TreeFam; TF333311; -.
DR Reactome; R-BTA-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-BTA-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-BTA-2559585; Oncogene Induced Senescence.
DR Reactome; R-BTA-69231; Cyclin D associated events in G1.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000011059; Expressed in myometrium and 105 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24201; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24201:SF9; CYCLIN-DEPENDENT KINASE 4 INHIBITOR C; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 69..101
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 102..127
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 168 AA; 18326 MW; 489DF387B7AF051D CRC64;
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG
ANPDLKDRTG FAVIHDAARA GFLDTLQTLL EFQADVNIED NEGNLPLHLA AKEGHLPVVE
FLVKHTACKV GHRNHQGDTA CDLARLYRRN EVVSLMEGNR AEGAANLQ
//