ID A7RGP6_NEMVE Unreviewed; 3582 AA.
AC A7RGP6;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=SH3 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g238120 {ECO:0000313|EMBL:EDO49575.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO49575.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO49575.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; DS469509; EDO49575.1; -; Genomic_DNA.
DR RefSeq; XP_001641638.1; XM_001641588.1.
DR STRING; 45351.A7RGP6; -.
DR EnsemblMetazoa; EDO49575; EDO49575; NEMVEDRAFT_v1g238120.
DR eggNOG; KOG0517; Eukaryota.
DR HOGENOM; CLU_000146_3_0_1; -.
DR InParanoid; A7RGP6; -.
DR OMA; TINQMAT; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00176; SPEC; 16.
DR Gene3D; 1.20.58.60; -; 25.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00435; Spectrin; 27.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 28.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 21.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 15..84
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 3294..3401
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 3184..3241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3262..3285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3468..3582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 285..312
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 708..735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 804..831
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1528..1555
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2051..2078
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2474..2501
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2580..2650
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3187..3241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3495..3509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3534..3548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3582 AA; 410399 MW; 3EA4FC7D2FAA3714 CRC64;
MNKSCIRTLA PKTCLEEVEV ETDEEVEEVI EREVTQDVVQ MVSVPQVQVL YLIAKTNKDW
WSVRRTKSRE AGYVPANYVV EIEPKAVKKV TKKTTMVPEK VMVKRKVKKM VTLKEPSGPS
SQLKRREKRR GVQRHFTAHF DRDNVAVRQI TISNTYNRLI ETSEMRRLSL QKAIKYYHFC
HECEDMDLWM SNKTLAPKTC SEEVEVETGE VELVVRHPRQ ARQIKAKEGE VIGLWAGLKS
KANKRKGLLD EAYGQQGFLV DARDLMSWSA ELKESFISAE DPQDIASASE LIQQHEEKFD
EIQTRFERFD QLDEYGRNLL ATSPQAVQVK QSMAALKAEK AALSSSWAKR NDRLHQGLDL
QTFIRDAEHV DAVTASQETF LAKEDLGFGG WIKEKSQIAE DESFKDPKNL QGNLKRHKAF
EAEITANKDG IDRINKLRFG STLVVGYVGG RTKSREAGYV PANYVVEIEP KAVKKVTKKT
TMVPEKVMVK RKVKKMVTLK EPSGPSSQLK RREKRRGVQR HFTAHFDRDN VAVRQITITN
TYNRLIETSE MRRLSLQKAI KYYHFCHECE DMDLWMSNKE RQFKSIESQN TLDAIQTVRQ
KLERFATEIA TKCSRVSDIN QLADELIQDG HAHSAAVKAK RKEINERWEK LQRLKVKEEE
NLAEKHGVEL FLDVCEEMRS WIQEKDAALC KEELGKDIET VRAQLRRHQG IERDLAAVED
KVAKLQDQAK SLVVRHPRQA RQIKAKEGEV ISLWAILKSK ANKRKGLLDE AYGQQGFLAD
ARDLMSWSAE LKESFISAED PQDIASASEL IQQHEEKFDE IQTRFERFDQ LDEYGRNLLA
TSPQAVQVKQ SMAALKAEKA ALSSSWAKRN DRLHQGLDLQ SSVDEVEWLL KKHEDFVKTL
TAQEEKVRSL ADMAKTIIHA RHQARDWVAS RAESVINRRD NVKNQASDRQ KALLTSQVLQ
NFIRDADEFG GWIKEKSQIA EDESFKDPKN LQGNLKRHKA FEAEITANKD GIDRINKAGK
DLIRTKHFGA QKVKDKLKGL NEAWLNLVAD TTEKGNKLQQ AERQRQLNRA MEDVRIWMNE
TEAVLGLEDT GRDLAGVKFL TKKHQLLESD IEMHATVIVD VADKAQELVS QGHFNSDTIK
SDSENLQSRY RSLLCLTDKR RSVLEDAFAL HQFIYDIEVE MTWVREHLQQ ASSGDLGTSL
ISVQRLQKRH LAFENELTNH QTRIDTVLSS GQDLIDSCYS ATDKVEERCE ELQNLWDELV
DMAAQRKQRL HDSFLSQKYL SEANEADSWM NDKAGLAASQ DYGKDGASAE TLLTRHKALQ
VDVAAFSTTI DELAEEARRL VQSSHFDSEK ISSTQRDLEE QFCGLNTLVK TRHTRLTESK
KLHEYRREVE EISAYVSEQL QTAASEDYGT DFEHLQVIQG RFGDFQRSVA SYAENFRNVD
NLAKMLVSEG HTDTVAIKEQ QDITRSMWLH LEDQIRLRQK RLTSAEEIHR FNRDLNELIS
RIQEKDAAIN LEDLGRDLAS TQVLQRKHEV FECELVTLEK QIEELTVESA RLQATYQGQT
ARSVEQHEKY VLSLWEELKR KTSRKRRKLH DAYEFYKLGN TVRDLISWCI ETSRLIASDD
PVHTVSDAER MMRELDEHHA EMDAREESFA RVLETGEKMI EDGHFAEEEI TDKLELLLSE
RERLYASWDT RKEELSEAYY LHVFLKDAKQ VDSFTSSQEA VLLCAELGNS VDEVEFLLKK
HENTEKLVLS QEEKLSALQV LGKELIDNQH NQSDMIRNRL SGVCDRREKL KAELDKRREK
LQNSHKIMQF YQDVVESESW IMEKLQTATD ESFKDPINLE SKLQKHQAFE SELTAHERAI
DSVRDKGEQL ISCGHFAASE VEVRIEALYI QWEELLEASA TKGRKLQEAR DHQQFNQEVD
IADSCITDKE TIVLSSDYGR DFEHCVRLQR KMKEFDQDLA VDAARVEAIN VLAEKLIGQG
HAGSVRIQQR QNALTERWNR LQDKASERRQ KLAEACEIHA FNRNCRDVSS MINEKAAVQT
SGEVGRDLPA VEALIRKHDD VERELTVIEG KMEELEGEAY RLVRSQPHMA RAVQAKQADI
IEQWERLNDL FDQRKVILEA NRLLQIFLVD YRDLMSWMND LGTRMSSGEL ADNVRDAEAM
LGLHEERKGQ MNARMDSYNA TVAFGMSLVE QGHVSADVIK QNVDDLVLEN TELQQLWQSR
KLMLQQSTDL QMFLADAEKA ENWIKNKQMV AQSIESRESL DNVESLLKSH INFEKSLSTY
EENIRSLESS AKQFLQVKHY HAEAIRSKYL EILDKWEALK KLAASRSGKL GESKLLFQFL
RDAKELESWM NEKLQIAAEA SYREATNLQQ KLQKHQTFEA EVSAHKSELD AITQTGQSLM
RNSPSCQETV ESRLKDLADL WSLLGDLSDN KAQRLKEAIQ KQTFERNVIE LQAWIEEVEN
ALASEDYGKD MRSVNNLIKR HQSLQMDIAR YEDRVSELLK QAGEFVAAEH FLKDEIADRA
ADVAERFEQL VEPATERELR LQDSLALHQF LADTQVEVDW IKDKEPIAKS EDYGRNLLGV
QSLMKKMEGL ESEINSHELL VQALLETGEQ LVLRGHYAER DIGAKSQMLL ELWEELRINA
QTRNEKLQAS LATHQYYDQV FEMDAWVSEK LSLVSSTDYG RDETSAETLL RKHDALQLEL
DANESKIRDL RSIYSELSDA GDTEFSKLEK IQDELEERYT HLRDVARDRH RRLLDSSRLF
NFLREADELG AWVEEKEAIV SSDDCGRDLE HVEMLMQKFE VFTRDLVSSG ERIAKLTEHA
QMLLDDEHTD SEMIEQRAEV ICERWDGLKE RTSTRLEELD RARDLHAFRR SVDEIHAWIQ
EKIDALGVAE NGAPDLRHVQ ALQRKHQGFQ RDLQALGEKV DLVLRDADDL SAKVPAHKHE
LIMEKQEVQK AWKKLQQLAS SKQSHLLQSE GLQAFLDDYR DLMSWIETTS AQVAEETLGS
TFADVETLIA QNQELQTEID SRANSVEEFQ SRADQLLGSG NPSAEDIRNK SSHVRDTWDR
LGASLRTRTQ QLQHNKEIQR FKREADQLEA WLNAREHDLL SEDVGDSLEA VEELLKKQDE
FEKMLLTQGE KFNSLTNTSF SVHKKSCAPK QVNSEEARTV KAVTDSVVAK PGIDVAKEIP
EQMNGLSEVK ESKSVSAESM DSFGNASAAR TSSPFNAVSP QRQLDSSDKA SSTQTSSPFK
AVLPQRPINT ADEVTNLINA SNLKSSLSES PAEKEQVRSP LEFDPGPKEI QKTLVVLEGM
LRRRQELQTA GRNAGSNIWQ NLYSVLIDKS LLFYGDKKSF SGGGNQVSPQ IELRGSRLHV
EEESTNHEFR LLLPDGSQFL FRCKDVLDFH RWTNEIEAST NDGEDVQSNG GHEKIETDQI
SPMSLDKVPP YSQLASDDVI DYGDGEVISE EDILAEFYPD APLDFNDNSI DNIPAPPLEF
DGLDEGDVDD DLTGLPVAPP PPVPVSTEVE PMRPPRKMRA PPPPSTRIPD VRYRSSSQDS
RDSDELPDIL PPPKPPIKPK PKVPEDKRHK PKGVFGIFKK KK
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