ID A7RIA7_NEMVE Unreviewed; 579 AA.
AC A7RIA7;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=NEMVEDRAFT_v1g238481 {ECO:0000313|EMBL:EDO48669.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO48669.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO48669.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469512; EDO48669.1; -; Genomic_DNA.
DR RefSeq; XP_001640732.1; XM_001640682.1.
DR AlphaFoldDB; A7RIA7; -.
DR STRING; 45351.A7RIA7; -.
DR EnsemblMetazoa; EDO48669; EDO48669; NEMVEDRAFT_v1g238481.
DR GeneID; 5520927; -.
DR KEGG; nve:5520927; -.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_471189_0_0_1; -.
DR InParanoid; A7RIA7; -.
DR OMA; MAHAYCH; -.
DR OrthoDB; 2915239at2759; -.
DR PhylomeDB; A7RIA7; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF7; RHO GTPASE-ACTIVATING PROTEIN 19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 61..264
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 412..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 65482 MW; 0093C944686E190B CRC64;
MSKNDARDPY GSICLSRLTR ILDLKMLEDL QELENSGNVA KNLELERHFK PHRSFLEKST
EKFNKIIHRK HHHHIFGHPL TNESVERILP LIHYLKTCVD KEGLFRISGN KKRQEELKEL
IDRGDTPKLG CGKFTAHDVA SVLKQFLGEL PEPLLTQAPY RAYLQVTEIS NDQGNAKHVE
ALQLLFLMIP PENRSLLHNL LELLKLVLEN PNNKMTAYNL AVVFCPNVLY CNKQRGSCIS
SFPQELDALN ESVAFMITFA KQLFQIPDDL KKELKLIEKN ISIGKEDEVP MAHAYCHQLD
NREHRETTQQ ATTEALVELY NHVKDMPDGP MKQKFMEKFE KTHPGTPPFM PRSRARTKPV
DQAMKPSLLT YSTPIKSTCT PGSLARPPLS PINANNTMDQ TSHHKNVTFR SPDVPAHRPS
HSRSVAAKAS YTPSGVMSPF KSPHRSGGKV FPRHKRTLSA GNSSMSPFRR SRTRTAHAPS
VPALTIQTPS GRMVCSPDPY NQPGAKIRKL YGSPAAKKRL SSRDYQRVST VPALFSLYDS
YSVKKMTYGR VRRTSTHAQK SLEREQGEAP PMPLASHSR
//
