ID A7RJR9_NEMVE Unreviewed; 495 AA.
AC A7RJR9;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=NEMVEDRAFT_v1g238793 {ECO:0000313|EMBL:EDO48317.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO48317.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO48317.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469514; EDO48317.1; -; Genomic_DNA.
DR RefSeq; XP_001640380.1; XM_001640330.1.
DR AlphaFoldDB; A7RJR9; -.
DR EnsemblMetazoa; EDO48317; EDO48317; NEMVEDRAFT_v1g238793.
DR eggNOG; KOG4424; Eukaryota.
DR HOGENOM; CLU_551317_0_0_1; -.
DR InParanoid; A7RJR9; -.
DR PhylomeDB; A7RJR9; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF275; LD03170P; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 199..375
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 77..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 56705 MW; 530E4B7AF99BAF71 CRC64;
MHRLVNAIGM HNTTSKLVFL LKFPLAFFNQ IYILKLDKNS EGLIPISPFS FETPPPLPAK
QVRTARLIDL DDKPQVAKPC PLSPVEGDLP PELPAKHRDR WSTSFQSDLN HNSSIELENE
NGIRNEESQS YDHNSPISKL DEQCASTSQE SIEKAELMNF GKGIKRNEEH RNSTVGASSF
MGLQLLQSKD SSEDTAEKRR TRAAEELLTS EMSYFSGLNM LISNYLSPLR ESHIISDDDI
KRIFSNVESH PDYGNLKEAQ AKAQKFSYLK LFEPYFNSRN KGNEVKSKLE KNNEKFRLIS
TRTKNGQTLN SLLLMPIQRI PRYELLLKEL VKRTDEIITS GWSGKTTTDL ETHLRKELRK
KSFDIGIILA GTNDLGVKEP EEGKPLFGRI KYLHELFLKH NKNTKTVALT LPETGYELSV
TWVREKRKNV NEMLKAYSDE SAGRVVLCDF AEEFPRERLC EEELNKFWDD GLHLTPQGYD
RMAEIIFDAL RPLLL
//
