ID   A7RPT5_NEMVE            Unreviewed;      1447 AA.
AC   A7RPT5;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   13-SEP-2023, entry version 69.
DE   RecName: Full=PH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=NEMVEDRAFT_v1g200293 {ECO:0000313|EMBL:EDO46561.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO46561.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO46561.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
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DR   EMBL; DS469526; EDO46561.1; -; Genomic_DNA.
DR   RefSeq; XP_001638624.1; XM_001638574.1.
DR   EnsemblMetazoa; EDO46561; EDO46561; NEMVEDRAFT_v1g200293.
DR   HOGENOM; CLU_251541_0_0_1; -.
DR   InParanoid; A7RPT5; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   4: Predicted;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          13..118
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1287..1421
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          505..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          747..780
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          888..909
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          959..984
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1193..1235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..558
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..596
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..626
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..648
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..686
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1447 AA;  161831 MW;  5CEA7E54E6208BCD CRC64;
     MALPGSRITS RLPQHLEGYL TARSKSGPKF PSKKSYFVLQ GELLRCYDSK ESYERSSKVK
     GQICLDEVCS ISESLVYKKS SATDIIKLVL LTGGEINLNA ENNDEVKRWV RGLQQSKEIW
     NELKKRQREE SSSVDTSLDE SLHFTQICFD NEAEQANDPS LIKVQIDMCK DRSFTIFVPP
     TCQVHELLNC AVDKIPISNC DKCQTCQLRC QMMELWMLDN TGQACRLESG AKINVVSSPR
     HFYLLEHNYK LLVVHFEDGR FSAKPVAMSI KAKQVPELFL SDLGLVCPDD FLLYLERPSK
     IATPFDPDDC PLYCFWESKN GRWSQPSIMP GRLLLKRRAL QVIDQYDVRM RQQELRLKKI
     IQDRRNQKVL KQIERQKCQQ PGRPNVPQQL RHPMTSWGPL IDTSGHDEDS LPCEDTDTAI
     RTVRTQAMGS QGSSTPHGQL TVPFGLPDDL DTFVVIEKPK AAVKNTQPSS VTHIVHKQPA
     LCCFEEPAPV MDASDWCVVD KTQTIQSSDS GTGSRQQGVG YEGNSGKKSG TSARQMYNHH
     HTGNREGFSC QKSGSLARQS YAPPCDRHDT GSVIEKKEQV ELTEEVQEDP RLYIRRTLGR
     RGGMRRRSSG KSIELTSNAT SVQEKRSPPQ GDRKIADFSS NDSSVHEQRP PSQGDREIAD
     FSSNDSSVHE QRPPPQDDRE LADFSANDSR VQEQRPPSQG DREIADFSSN DSSVHEQRPP
     PQDDREIADL SSNMALKLNE MICRPGEQSH DKLSKNSHAI DASESQKEIK TGGDFHGDRK
     SECVTQSEIF DGYIGQPSDV KSSKNYPRTR DSQADLHLAN HTLSSRTAIL SNQLKDCQFK
     APNSNAEMNI DPEFANSTGN SESLPGENIV YELSCPKEEE KKDAFINNSS LEGTSNNHPS
     SYGTQGSSNV STVECAKSVS LLSRGYDISK GRMMTQDIRQ TDIESESCRD GIGILSLDGS
     YDNQSTSTNK VDEDDSCPEA SAPSRTRHTC ELYPVTTPYI LRSILQQYAS TSQGEEEVGV
     ERPPRALCVD GIHISHRNGE WTSDLCTVES NGTSNITDDC ETFELSGGLL VLYHTVKRQW
     SVRHRKKSEV IADDEKQVGA LVLVTESKET SKQTRRLESL HPRLLVDGAE TKVNLIKCSS
     SSSSTLEPSS AFLPREDNEI RCVPSSDIQD MRLAINASED LLDGVERSSD SQLASVSSEC
     NTPSAYPFRG PPRTILNVGQ SLDPNQESRS ESEDLKLNHR SVENITRDPR DFLEIQFLED
     AIQKIFYHLE RQDDLPINAL DDKQYSVTRK LVCGSLCPAL VSLLSHGAKR RWTLKGYVTY
     SAWDIISGVS SKGRLSPLIK SIVEIGPLSS DLRFHLFVCG ALNKGSDMLA VWSEELQGSR
     HLLLEYFTED SVLVRTLQTS CLEEVLSRLS YLPFRLTLFE ENLAVVTRPY SGTHAPCRAE
     CLGFSGR
//