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Database: UniProt
Entry: A7RXH0_NEMVE
LinkDB: A7RXH0_NEMVE
Original site: A7RXH0_NEMVE 
ID   A7RXH0_NEMVE            Unreviewed;       755 AA.
AC   A7RXH0;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 81.
DE   RecName: Full=Histone acetyltransferase GCN5 {ECO:0000256|ARBA:ARBA00019713};
GN   ORFNames=NEMVEDRAFT_v1g96946 {ECO:0000313|EMBL:EDO43844.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO43844.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO43844.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. GCN5 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008607}.
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DR   EMBL; DS469550; EDO43844.1; -; Genomic_DNA.
DR   RefSeq; XP_001635907.1; XM_001635857.1.
DR   AlphaFoldDB; A7RXH0; -.
DR   STRING; 45351.A7RXH0; -.
DR   EnsemblMetazoa; EDO43844; EDO43844; NEMVEDRAFT_v1g96946.
DR   eggNOG; KOG1472; Eukaryota.
DR   HOGENOM; CLU_015901_0_0_1; -.
DR   InParanoid; A7RXH0; -.
DR   OMA; ERYFQTK; -.
DR   PhylomeDB; A7RXH0; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0140672; C:ATAC complex; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0010484; F:histone H3 acetyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd05509; Bromo_gcn5_like; 1.
DR   CDD; cd04301; NAT_SF; 1.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR037800; GCN5.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR009464; PCAF_N.
DR   PANTHER; PTHR45750; GH11602P; 1.
DR   PANTHER; PTHR45750:SF3; HISTONE ACETYLTRANSFERASE; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF06466; PCAF_N; 1.
DR   PRINTS; PR00503; BROMODOMAIN.
DR   SMART; SM00297; BROMO; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          431..577
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS51186"
FT   DOMAIN          666..736
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
SQ   SEQUENCE   755 AA;  86929 MW;  E1D0D8369C861508 CRC64;
     MNPSEFSRPV NLQRIAQRKA QVKTYPRRKK LEKLGVYSSC KVEDTCKCNG WKNPNPPPTP
     PRLDLSQPLA SLNDPCRSCG HSLGLHISQL QSISEDELDR LLCMVVDVEN LFMCVHKEED
     ADTKQVYFYL FKLLRKCILQ MSTPTVEGQL GTPPFEKPSI AKAVINFVLH KFGHLPQREW
     QIMHDLAKMF LHCLNHWKLE TVAMRKQHAE AEHIAAYKLN YTRWLCYCHV PVFCDSLPKC
     DTTAVFGRTL LRSVFSVMRS QLLEKFRAEK DKMPADKRTI VLTHFPRFLS MLEKEVYGES
     SPIWDDDFTV PQSLMAARAS STPVVTINAE SGESQTGCVA VHFYFLPKKY NVNQKFEESL
     GIVKSLTFIT DSDVPLDVLK QVVETISDPS AMIGPESGLY PGAHSARDEH ARCEERRGVI
     EFHVVGNSLR RMPSRLTQQW LVGLQNVFSY QLPRMPKEYI TRLVFDPKHK TLALVKDNRP
     IGGICFRMFP TQNFTEIVFC AITSNEQVKG YGTHLMNHLK DYHIKHGVLN LLTYADEYAI
     GYFKKQGFSK EIKIPKASYT GYIKEYEGAT LMHCQVNSCI QYTEFSTIIR KQKEIVKKLM
     SRKQEQIRRV YPGLTCFKEG VRQIPVESIP GISETGWRSS MNKSVTKEAD PSVLQTQLKN
     ILTQVKNHAS AWPFQKPVER AEAPDYYEHI KYPMDLKTMT ERLKSGYYSS KKLFVADMRR
     IFQNCRTYNS PDTEYYKCAN TVERFFLSKI KEPGK
//
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