ID A7RXH0_NEMVE Unreviewed; 755 AA.
AC A7RXH0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 81.
DE RecName: Full=Histone acetyltransferase GCN5 {ECO:0000256|ARBA:ARBA00019713};
GN ORFNames=NEMVEDRAFT_v1g96946 {ECO:0000313|EMBL:EDO43844.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO43844.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO43844.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. GCN5 subfamily.
CC {ECO:0000256|ARBA:ARBA00008607}.
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DR EMBL; DS469550; EDO43844.1; -; Genomic_DNA.
DR RefSeq; XP_001635907.1; XM_001635857.1.
DR AlphaFoldDB; A7RXH0; -.
DR STRING; 45351.A7RXH0; -.
DR EnsemblMetazoa; EDO43844; EDO43844; NEMVEDRAFT_v1g96946.
DR eggNOG; KOG1472; Eukaryota.
DR HOGENOM; CLU_015901_0_0_1; -.
DR InParanoid; A7RXH0; -.
DR OMA; ERYFQTK; -.
DR PhylomeDB; A7RXH0; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0140672; C:ATAC complex; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0010484; F:histone H3 acetyltransferase activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05509; Bromo_gcn5_like; 1.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR037800; GCN5.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR009464; PCAF_N.
DR PANTHER; PTHR45750; GH11602P; 1.
DR PANTHER; PTHR45750:SF3; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF06466; PCAF_N; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 431..577
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT DOMAIN 666..736
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
SQ SEQUENCE 755 AA; 86929 MW; E1D0D8369C861508 CRC64;
MNPSEFSRPV NLQRIAQRKA QVKTYPRRKK LEKLGVYSSC KVEDTCKCNG WKNPNPPPTP
PRLDLSQPLA SLNDPCRSCG HSLGLHISQL QSISEDELDR LLCMVVDVEN LFMCVHKEED
ADTKQVYFYL FKLLRKCILQ MSTPTVEGQL GTPPFEKPSI AKAVINFVLH KFGHLPQREW
QIMHDLAKMF LHCLNHWKLE TVAMRKQHAE AEHIAAYKLN YTRWLCYCHV PVFCDSLPKC
DTTAVFGRTL LRSVFSVMRS QLLEKFRAEK DKMPADKRTI VLTHFPRFLS MLEKEVYGES
SPIWDDDFTV PQSLMAARAS STPVVTINAE SGESQTGCVA VHFYFLPKKY NVNQKFEESL
GIVKSLTFIT DSDVPLDVLK QVVETISDPS AMIGPESGLY PGAHSARDEH ARCEERRGVI
EFHVVGNSLR RMPSRLTQQW LVGLQNVFSY QLPRMPKEYI TRLVFDPKHK TLALVKDNRP
IGGICFRMFP TQNFTEIVFC AITSNEQVKG YGTHLMNHLK DYHIKHGVLN LLTYADEYAI
GYFKKQGFSK EIKIPKASYT GYIKEYEGAT LMHCQVNSCI QYTEFSTIIR KQKEIVKKLM
SRKQEQIRRV YPGLTCFKEG VRQIPVESIP GISETGWRSS MNKSVTKEAD PSVLQTQLKN
ILTQVKNHAS AWPFQKPVER AEAPDYYEHI KYPMDLKTMT ERLKSGYYSS KKLFVADMRR
IFQNCRTYNS PDTEYYKCAN TVERFFLSKI KEPGK
//