ID A7RXK9_NEMVE Unreviewed; 534 AA.
AC A7RXK9;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Wiskott-Aldrich syndrome protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g241376 {ECO:0000313|EMBL:EDO43865.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO43865.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO43865.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DS469550; EDO43865.1; -; Genomic_DNA.
DR RefSeq; XP_001635928.1; XM_001635878.1.
DR AlphaFoldDB; A7RXK9; -.
DR STRING; 45351.A7RXK9; -.
DR EnsemblMetazoa; EDO43865; EDO43865; NEMVEDRAFT_v1g241376.
DR GeneID; 5515811; -.
DR KEGG; nve:5515811; -.
DR eggNOG; KOG3671; Eukaryota.
DR HOGENOM; CLU_015385_3_1_1; -.
DR InParanoid; A7RXK9; -.
DR OMA; SHASHNT; -.
DR OrthoDB; 3837860at2759; -.
DR PhylomeDB; A7RXK9; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR Gene3D; 6.10.280.150; -; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011026; WAS_C.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR11202:SF36; NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR Pfam; PF02205; WH2; 2.
DR SMART; SM00461; WH1; 1.
DR SMART; SM00246; WH2; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 2.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
DR PROSITE; PS51082; WH2; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 30..139
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 220..233
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 431..448
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT DOMAIN 462..479
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 138..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..430
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 57292 MW; 1793810286EBF1D9 CRC64;
MSTTRQKPKP VNIPSALLSN EENDSVFNML GRGCTTLATA VAQLLIALPE SRTKWTKKAT
GAVCFVKDCS KKSYFIRVYD IIQKCMVWEQ ELYNQFKYFT SLPFFHTFAA DNCNAALNFS
SNSEADAFKT QIEIKLQEKQ KRRQDRRNQH KNREPAPPPA LGGNVELSGR PASGTMTHSP
SQTSLTSIDS LSSKKKSTSG NNKKDKKDKK GKKKFSKDDI GNPENFQHVG HMGWDPQKGF
DVKNVDLSKH GDEWVKLFKL FGVSENQMDD STKAFVVNFV NERGGIEAVT KEIEKEYDTT
ASLGIQPPPP PSRGAAPPPP SRGAPPPPPS RGSAPPPPPA RMGTAPPPPP PSRSSQRPPP
PSRGAPPPPS MGMAPPPVGG AAPPPPPPPP VGGPPPPPPP IEGRPPSSLG NPPPPPPPGR
GAPPPGPMIP GRAGLLSQIQ MGTQLKRVGD DEKRKSMSGG DARDDLLSAI RSGTNLKPVS
QEDGQAKPRV DAAPGGILGA LQMALTQREK AIHSSDDDSD SASEFESDDD EWID
//
