ID A7RYS4_NEMVE Unreviewed; 1151 AA.
AC A7RYS4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Large proline-rich protein BAG6 {ECO:0000256|ARBA:ARBA00021614};
DE AltName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
DE AltName: Full=HLA-B-associated transcript 3 {ECO:0000256|ARBA:ARBA00029739};
GN ORFNames=NEMVEDRAFT_v1g204128 {ECO:0000313|EMBL:EDO43370.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO43370.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO43370.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- FUNCTION: Released extracellularly via exosomes, it is a ligand of the
CC natural killer/NK cells receptor NCR3 and stimulates NK cells
CC cytotoxicity. It may thereby trigger NK cells cytotoxicity against
CC neighboring tumor cells and immature myeloid dendritic cells (DC).
CC {ECO:0000256|ARBA:ARBA00002067}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
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DR EMBL; DS469554; EDO43370.1; -; Genomic_DNA.
DR RefSeq; XP_001635433.1; XM_001635383.1.
DR AlphaFoldDB; A7RYS4; -.
DR STRING; 45351.A7RYS4; -.
DR EnsemblMetazoa; EDO43370; EDO43370; NEMVEDRAFT_v1g204128.
DR eggNOG; KOG4248; Eukaryota.
DR HOGENOM; CLU_006890_0_0_1; -.
DR InParanoid; A7RYS4; -.
DR OMA; NRITVAM; -.
DR PhylomeDB; A7RYS4; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0071818; C:BAT3 complex; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd01809; Ubl_BAG6; 1.
DR InterPro; IPR021925; BAG6.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR019954; Ubiquitin_CS.
DR PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR Pfam; PF12057; BAG6; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00299; UBIQUITIN_1; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 1..62
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 70..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..515
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1151 AA; 124075 MW; 5EE3475F1E9BDD73 CRC64;
MQVTVKTLDS ETRTFTVSEE LTVEEFKKEI ADTVGIPAER QRLIFKGKVL QDEKKLKEFE
VDGCVVHLVE RKPPRTQPDG ASNSPDGPSV HPGSQAASSA ANIVMGAFNM PVDVMGISQN
IVQGLVSHLG VDASHANVSS SHSSDGSTLN VHINLLSAPP EGNDAARRLS RARHFVRAAR
ESFNRTEGEA PSSMDANVPT DDRPAPNQGP QGNTEQPRPS DLADVLGELQ EFSSQLQPSL
NRYTSLLNSP ATENLLPSDD SLPDRIAETL HNLSHAYHAL SDLSINIRAP EPRRLSVLTP
LSPHVGAPNL LSSIFGGRPP PGPTTSRQNV SGQAGPTNMT QSSTSHSSTP RHHGEPQTTI
SITSIISSAI PRGHMPTTPS TTPQATPPST TSQTTAPTAS QAPSAGETPQ PSTATTGEEA
RVMMDDFVNL ISNLGQMTHG HPAASASQGA GQTGLHVHIG PRPPMGPPPP PGFNLHTGPR
LHMGPPPSGF HAQRGPQPEM GPTPQPHPYV PPMGPIRVNP TQAHRQGMAH PDPSLPCESF
HFGLRAHRAQ PSQQPGEAQG TQQPGSAPTQ GTQQSESAPT QGTQQSGSSS VEGPGRVFEQ
LVASVVQNAV SGGAALAQQA QTPDSLKPQT VSSPRQSQTP DSLKPQTVSN PRQSQTPDSL
KPQTVSNPRQ SQTPDSLKPQ TVSSPRQSQA PDSLKPQTVS SPRQSQAPDS LKPLTVSSPR
QSQAPDSLKP QTVSSPRQSQ APDSLKPQTV SSPRHLYVSI AYQTLNDVIL ELQNRGLDTS
SEPISIQGAL LSQDYQDWNI FIHAGYAGHH AGLRVVLRSY LFTDLLLGEE ATESRLQELS
VQFVSQVLDE IAPILTSEST CDGIDVVATV RKFLEYFAKR AFTLIRDADE QTFCNAFPFM
VRGMSSDFVQ LLALCYQNGL RDVENIITNR LPGTIVARDM GPVMLRTFRE TLLRYVRDAS
QVPTQTNLQD YIIKASQEQK GSSQSVKPMP SDTVPVCQPD TAEDMSQNSD DSFHTPPGSV
VTGGPEASQL AIDQGEVHMA VDDLEDDWKA VVPEEWVPIL AQDVMRQRRI PPQQPFSDAY
LSGLPPKRRK AMLATGAPRN SIDAVTESAR TNSKLHQAYR EEVKETVKKR TDTDTDFSSE
RFPVTSQYTC K
//
