ID A7S157_NEMVE Unreviewed; 1130 AA.
AC A7S157;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO42539.1};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g20232 {ECO:0000313|EMBL:EDO42539.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO42539.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO42539.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR EMBL; DS469563; EDO42539.1; -; Genomic_DNA.
DR RefSeq; XP_001634602.1; XM_001634552.1.
DR AlphaFoldDB; A7S157; -.
DR STRING; 45351.A7S157; -.
DR EnsemblMetazoa; EDO42539; EDO42539; NEMVEDRAFT_v1g20232.
DR eggNOG; KOG3209; Eukaryota.
DR HOGENOM; CLU_004562_1_0_1; -.
DR InParanoid; A7S157; -.
DR OMA; PPTYLYN; -.
DR PhylomeDB; A7S157; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316:SF40; LD27118P; 1.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..80
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 87..186
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 224..257
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 271..304
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 344..413
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 513..576
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 684..766
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 843..925
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1051..1119
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 178..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO42539.1"
FT NON_TER 1130
FT /evidence="ECO:0000313|EMBL:EDO42539.1"
SQ SEQUENCE 1130 AA; 125439 MW; AD1714EA03280FC8 CRC64;
RKGKHWSHHV RESIVCKSKE GSFNLKIVGG AEFGEFINIG DLKEDKVVYK KGKLLCGDVI
LEINNKPVAG YTRPDVLELI SKDGRNAVSL RTVKPGLGIT KDLRQFLAGR FDSDSVDSAL
QLTIRENLYR RTVPCTTRSP RNGEIPGVDY VFLNMQQFMD MEKSGALLES GVFEGNHYGT
PKPPIQPAGT LSAPASKRQG RPSSATKWKK GPLNGDMPSG DMLGPLPDNW EVAYTETNEK
YFIDHKTGTT QWVDPRLASK KSRRPEDCDD DELPYGWEKV DDPKYGTYYI DHINKKTQFE
NPVLAVRHSQ DGLDSYDNDT SYMRPPPHQT FYIEGRRLEG ELIRTELMKG FRGFGFTIIG
GDQSGELLQI KSIVPDGAAA KDGKLRTGDA LIKVNGRSVV NKTHQEVVSM FQSMPTNEPI
ELDMIRGYPL PFDPDDPNVE TIGSYTVVRS PQGDNQSGLL QPANKYGLPN AHSDQSISSS
NTDSPAGNRG YNTASFPRHS TSTLQRSTPE MHNVRIVKGP MGFGFTIADS PYGQKIKQIL
DAQRCENLME GDLLMELNGY NLRNYSHTET VDMLKNCPKG REAVILIQRG GRCNYSWRKP
RPKSTPPMGA VQVLPMGPPP SQRMGSAGNL ATSGEATRNQ EIGSGRGGNQ AYFDKGGDAL
TQSYPPIRKA VHLNRGHDDS VDYYITLHRG ESGFGFRIVG GKEDNTQVAI GTIVDGTPAA
ADGRLRRGDE ILYVDGVSVI DGYHRDVISL MKSAAQNGQV TLGVRRRQTM PGRSTPSGVR
RTSQSNSVRL TSRSAGNLTE LARRDEYEPN GFRSPSERAG STRDRRRSES DKLQPDIPMD
YRDITLNRGA HEGFGFVILS SVHKSGSTIG RIIQGSPADR CRELYVGDKL VAVNGTSIVG
MHHSDIVNTI KQSGLSVTLR IAQKPLGKTD SNKANHEERR KQEELKLRLQ EEARRQEELA
RQRTQPERKV PPPVLPKPSK NKVLQARGQF EQNTKYQTLP ARTALPEDRY RRMSGGESQP
PPGQRVFKPR PKSESELMRD PRTGEVTQVL EIELIRKNQG YGFSIRGGQE MDMPIYVLKI
AEGGVADLDG RIKVGDEVLE INGRSTQHML HTDAISMIRG GSKVRLVLRR
//
