ID A7S3D9_NEMVE Unreviewed; 934 AA.
AC A7S3D9;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Protein transport protein Sec24C {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g103120 {ECO:0000313|EMBL:EDO41706.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO41706.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO41706.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; DS469573; EDO41706.1; -; Genomic_DNA.
DR RefSeq; XP_001633769.1; XM_001633719.1.
DR AlphaFoldDB; A7S3D9; -.
DR STRING; 45351.A7S3D9; -.
DR EnsemblMetazoa; EDO41706; EDO41706; NEMVEDRAFT_v1g103120.
DR eggNOG; KOG1984; Eukaryota.
DR HOGENOM; CLU_004589_1_0_1; -.
DR InParanoid; A7S3D9; -.
DR OMA; INPFMTF; -.
DR PhylomeDB; A7S3D9; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 261..299
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 338..581
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 587..670
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 683..783
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 803..872
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..78
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..142
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 103543 MW; C1C80E149669B9D2 CRC64;
MQRPGGPPTS QPGGFQHQQR PGAPPTSQPG FPSPQMQEPM QLPTSQPGGF PPQQRPGAPP
TSQPGAQMLP PMPGPPSSMS GPTTSRHGPP PTGLTMNPPT SMGMAPMMPP PGPGMGTHPQ
QPYPGGPPSM SGMPPPPGHS PHMGGRGPSM NSPMQQQKRI DPDQMPSPIQ VMKDDRETHK
DQPFMTNTRD RIPPLVTSSF VVKDNGNCSP RFIRSTMYNV PCNKDLLQAS DIPLAAIITP
FAQIPAEEGY LPIVNHGASG PVRCNRCKAY INPFVQFIDG GRRFVCNICT YSSEVPADYF
CHLDHQGLRV DLYERPELHL GSYEMVATAD YCKDQKFPGP PAYIFMIDVS YQSMQCGMVR
LLMREMNELL EHLPKEFNSE QSQVRVGFVT YSNQLHFYNI KGNLAQPQMM VVSDVDDMFV
PLLDGFLVSV DEARSVIESL LEQIPLMFAE TRDTETVLGP VVQAGIEALK SAGISGKLFI
FHSSLPITEA PGKLKNREDR KLLATDKEKT ILSPQTTFYE NLAKQCVEAG VAVDLFLFPN
AYVDVATIGA IATQTGGDIY RYSYFKEVTH GEQFREDLKR AIECNMGFDA VMRLRTSTGL
RPVDFVGSFY MSNTTDVELA GISPNKAIGI EIKHDDKLPE DSTAYLQCAL LYTSISGQRR
LRIHNLALNT CSQLSELFRC CEMDSFVNYV SKKAIRAVLT TAPKDIREQL VNQCAQILAC
YRRNCASPSS AGQLILPECM KLLPLYINCV LKSDALVGGS EMSSDDRSWL MRRVISMDQN
ASVPYFYPRL FPVHDVDVEA TGLPEQIRCS IERMSDNGIY VLENGISMLL WVGLQVDPGM
LQQIFGVSTI GQVDIEMTSL PVLDNPLSAR IQDIISSIRA ERPNYLKLTV VRQRDKLEPW
FKHFLVEDKG MSASCPSYVD FLCLMHKEIR NLLN
//
