ID A7SAX6_NEMVE Unreviewed; 893 AA.
AC A7SAX6;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=NEMVEDRAFT_v1g209451 {ECO:0000313|EMBL:EDO39124.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO39124.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO39124.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; DS469612; EDO39124.1; -; Genomic_DNA.
DR RefSeq; XP_001631187.1; XM_001631137.1.
DR AlphaFoldDB; A7SAX6; -.
DR STRING; 45351.A7SAX6; -.
DR EnsemblMetazoa; EDO39124; EDO39124; NEMVEDRAFT_v1g209451.
DR eggNOG; KOG0196; Eukaryota.
DR eggNOG; KOG0200; Eukaryota.
DR HOGENOM; CLU_323741_0_0_1; -.
DR InParanoid; A7SAX6; -.
DR OMA; VKYIPNT; -.
DR PhylomeDB; A7SAX6; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.1770; ephrin a2 ectodomain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR Pfam; PF01404; Ephrin_lbd; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR SMART; SM00615; EPH_lbd; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51550; EPH_LBD; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..893
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002715151"
FT DOMAIN 12..194
FT /note="Eph LBD"
FT /evidence="ECO:0000259|PROSITE:PS51550"
FT DOMAIN 323..420
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 421..513
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 491..866
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 893 AA; 96162 MW; 6D9CA01E0855DC8A CRC64;
MKVWVYLVVD LLVFLYSSHA ERVLLANFMN GKPWRERWTS SASSSWDLSR SELGACDSSL
SQPNGWVRSD VINTGPATRI ELTATFDARD CSSFSVGSYC RHDFDVYAHQ SETQYSGLAP
DPNNSPPQTY SKMGTLNATK LWTSFGNKTQ NVQTLSLILE NSKPYVYLAL HYKGGCLAVQ
SILVEYFRCM NMTLPSTLVQ LGATVAPANN SINVSGACAP NSKQVSGAGD LYGYCQSDGE
WSSGLFSGEC QCEAGHQNTT TGGGGAECQA CKVGTYKAVH GYFVCASCPD NSVAMEIGST
SCTCVRGFYR KANESISSAC TGPPSPPTSL YKPFLNSSAI ILSWSAPNNT GGRTDDDGSV
CVEACGGTVA QQGTSARVSG LSAFTYYMFR VYARNGVSDE AEMGGQDAEF AKLVIRTRDA
VPGKPEITAV EKVDLTLVRV SWKLLKHNGI ITSYELKYHV TGKSANEKSV TINATRATVD
IDRDKGYQFR VRAQTRLGYG PFSDAVSLQA GQTSSSSSSP LVIGTSVLGA VLVLVILLVS
AQEEYDDIGE TNPGLDAIYS CVGEDEAWEV PPQNLSVIKR LGSGNFGHVD KAMAIGIPGF
PGQVTVAVKT LKYYLAIILE YLPYGDLLGY LRRSRGHEDW YCSGDLRPPS RLVSKDLVKF
AWMIADGMAF LAANKCVHRD LAARNVLVGE HNTCKISDLG LARDVSQDIY TRTSSMVLWD
SSLGDFYNCV VVPLSLAGQT GSSSSSPLVI TTSVLGAVLV LAILLVAAQE EYEDMGETNP
GLDTIYSCVG EDEAWEIPPQ NLSVIKRLGS GNFGHVDKAM AIGIPGFPGQ VTVAVKTLKS
TAQKKDKTDF LTELNLMKSL RPHPHVVRLI GCCTRQTGEL SSTISEFQVA SNS
//
