ID A7SCI2_NEMVE Unreviewed; 376 AA.
AC A7SCI2;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=NEMVEDRAFT_v1g113345 {ECO:0000313|EMBL:EDO38581.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO38581.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO38581.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469623; EDO38581.1; -; Genomic_DNA.
DR RefSeq; XP_001630644.1; XM_001630594.1.
DR AlphaFoldDB; A7SCI2; -.
DR STRING; 45351.A7SCI2; -.
DR EnsemblMetazoa; EDO38581; EDO38581; NEMVEDRAFT_v1g113345.
DR eggNOG; KOG2200; Eukaryota.
DR HOGENOM; CLU_023268_0_0_1; -.
DR InParanoid; A7SCI2; -.
DR OMA; QHNMESQ; -.
DR PhylomeDB; A7SCI2; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF1; RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 41..239
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 376 AA; 43480 MW; A64180C2868D39CD CRC64;
MEKVRSLALI ELTALFDQHG IALHRRKPIK KKVKECGIFE VPLQYLVQHD RLKGSNSNVP
LFLQEMIRFL DHNSLTEEGI LRVGGATARM KALREEIEET FNEGAFSLDG RRVHDVAGLL
KQFLRELPFP LLTYEYQPTF ASVENIPDRR QQLQALNLLI LLLPSIHRDC LRVLLTFLSR
IISYEKQNKM NLNNVSMIMA PNLFHFSSSK EMPSLREVKQ AQATVNLVRM LIKYQNILWT
IPGFMVMQVQ KMNVQRTKEL WTKERPKNKR IVDKRKSNEQ KNCGQKNAEL ANNIIRVKAP
MLNKIAMAIQ LTDGMRAGDI VAKFRRRPGE DAEGHHLYEV GGNIGERCLD NDTNMKALYK
VNPHAEWIIK PRSDYE
//
